Brian F Saway1, Islam Fayed2, Ehsan Dowlati2, Roshanak Derakhshandeh3, Faheem A Sandhu2. 1. Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA. Electronic address: saway@vt.edu. 2. Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC, USA. 3. Department of Pathology, MedStar Georgetown University Hospital, Washington, DC, USA.
Abstract
BACKGROUND: Pancreatic neuroendocrine tumors (pNETs) are known to frequently metastasize to the liver and lymphatics; however, metastasis to the spine is exceedingly rare. We report the first case of an intradural, extramedullary pNET metastasis to the upper cervical spine. CASE DESCRIPTION: A 75-year-old Hispanic male patient with history of stage IV pNET with metastasis to the liver and lymph nodes and new-onset lymphadenopathy seen on CT of the chest was found on positron emission tomography scan to have a lesion in the cervical spine. The patient was neurologically intact on physical examination, yet given the patient's medical history, magnetic resonance imaging of the cervical spine was performed, revealing a right-sided intradural, extramedullary mass at the C1-C2 level with associated mass effect on the spinal cord, likely representing a schwannoma. Due to the tumor size, mass effect, and the need for definitive tissue diagnosis, a partial C1-C2 laminectomy with intradural resection of the tumor was performed. The histology was consistent with the patient's known pNET. CONCLUSIONS: As treatment for pNETs has evolved, there has been a surge in unique presentations of systemic well-differentiated pNETs being reported. It is vital that patients diagnosed with pNET be monitored for metastases, and when discovered, treated promptly.
BACKGROUND: Pancreatic neuroendocrine tumors (pNETs) are known to frequently metastasize to the liver and lymphatics; however, metastasis to the spine is exceedingly rare. We report the first case of an intradural, extramedullary pNET metastasis to the upper cervical spine. CASE DESCRIPTION: A 75-year-old Hispanic male patient with history of stage IV pNET with metastasis to the liver and lymph nodes and new-onset lymphadenopathy seen on CT of the chest was found on positron emission tomography scan to have a lesion in the cervical spine. The patient was neurologically intact on physical examination, yet given the patient's medical history, magnetic resonance imaging of the cervical spine was performed, revealing a right-sided intradural, extramedullary mass at the C1-C2 level with associated mass effect on the spinal cord, likely representing a schwannoma. Due to the tumor size, mass effect, and the need for definitive tissue diagnosis, a partial C1-C2 laminectomy with intradural resection of the tumor was performed. The histology was consistent with the patient's known pNET. CONCLUSIONS: As treatment for pNETs has evolved, there has been a surge in unique presentations of systemic well-differentiated pNETs being reported. It is vital that patients diagnosed with pNET be monitored for metastases, and when discovered, treated promptly.
Authors: Roberta Costanzo; Massimiliano Porzio; Rosa Maria Gerardi; Caterina Napolitano; Sandro Bellavia; Maria Angela Pino; Francesco Bencivinni; Maria Aurelia Banco; Rosario Maugeri; Domenico Gerardo Iacopino; Ada Maria Florena Journal: Surg Neurol Int Date: 2022-05-13