Literature DB >> 32343979

The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.

Wei-Chieh Mu1, Rika Ohkubo1, Andrew Widjaja1, Danica Chen2.   

Abstract

Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged stem cells. Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the feasibility to target this checkpoint to reverse stem cell aging. We discuss the mechanisms by which mitochondrial stress leads to stem cell deterioration. We speculate the therapeutic potential of targeting the mitochondrial metabolic checkpoint for rejuvenating aged stem cells and improving aging tissue functions.
Copyright © 2020 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  NLRP3; SIRT2; SIRT3; SIRT7; Stem cell aging

Mesh：

Substances：

Year:  2020        PMID： 32343979      PMCID： PMC7375904          DOI： 10.1016/j.mad.2020.111254

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  63 in total

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  4 in total

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