Prevention of IOP-rise following Nd-YAG laser capsulotomy with topical timolol and indomethacin.

Short term observation following Nd-YAG laser capsulotomy indicates that serious elevation of intra-ocular pressure may occur, unrelated to the amount of incident energy used. In this study we evaluated the effect of pre-treatment with anti-prostaglandin eyedrops on the rise in IOP. The IOP in forty pseudophakic patients, undergoing Nd-YAG laser posterior capsulotomy, was measured before capsulotomy and 2 and 4 hours afterwards. The fellow-eye was used as a control. Thirty minutes pre-operatively the patients were given one of the four following combinations of eyedrops: 1 drop timolol 0.5% and 1 drop placebo, 1 drop indomethacin 1% and 1 drop placebo, 1 drop timolol 0.5% and 1 drop indomethacin 1%, 1 drop placebo and 1 drop placebo. Statistical analysis of the results showed that indomethacin alone has little influence on the IOP-rise, whereas timolol has. When indomethacin is added to timolol there is no significant enhancement.

RCT Entities:   Population Interventions Outcomes