Literature DB >> 32340990

Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.

Charlotte Avanzi1, Raquel Cristina Maia2, Stewart Thomas Cole3,4, Milton Ozório Moraes5, Andrej Benjak1, José Augusto Nery2, Anna Maria Sales2, Alice Miranda2, Nadia Cristina Duppre2, Amanda Nogueira Brum Fontes6, Tatiana Pereira da Silva2, Roberta Olmo Pinheiro2, Fernanda Neves-Manta2, Suelen Justo Maria Moreira2, Philippe Busso1, Euzenir Nunes Sarno2, Phillip Noel Suffys6.   

Abstract

A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Mycobacterium leprae; leprosy; relapse emergence; resistance; rifampin; treatment; whole-genome sequencing

Mesh：

Substances：

Year:  2020        PMID： 32340990      PMCID： PMC7318023          DOI： 10.1128/AAC.00330-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Molecular detection of drug resistance in Mycobacterium leprae.

Authors:  Diana L Williams; Thomas P Gillis
Journal:  Lepr Rev       Date:  2004-06       Impact factor: 0.537

2.  Identification of primary drug resistance to rifampin in Mycobacterium leprae strains from leprosy patients in Amazonas State, Brazil.

Authors:  Matilde Del Carmen Contreras Mejía; Maísa Porto Dos Santos; George Allan Villarouco da Silva; Isabella da Motta Passos; Felipe Gomes Naveca; Maria da Graça Souza Cunha; Milton Ozório Moraes; Lucia de Paula
Journal:  J Clin Microbiol       Date:  2014-10-01       Impact factor: 5.948

3.  Classification of leprosy according to immunity. A five-group system.

Authors:  D S Ridley; W H Jopling
Journal:  Int J Lepr Other Mycobact Dis       Date:  1966 Jul-Sep

4.  Genotyping of Mycobacterium leprae from Brazilian leprosy patients suggests the occurrence of reinfection or of bacterial population shift during disease relapse.

Authors:  Adalgiza da Silva Rocha; Alexandre Araujo Cunha Dos Santos; Patrícia Pignataro; José Augusto Nery; Antônio Basílio de Miranda; Diego Fonseca Soares; Amanda Nogueira Brum Fontes; Alice Miranda; Helen Ferreira; Neio Boéchat; Maria Eugênia Novisck Gallo; Euzenir Nunes Sarno; Maria Leide W De Oliveira; Philip Noel Suffys
Journal:  J Med Microbiol       Date:  2011-05-19       Impact factor: 2.472

5.  Multidrug resistant Mycobacterium leprae from patients with leprosy.

Authors:  S Maeda; M Matsuoka; N Nakata; M Kai; Y Maeda; K Hashimoto; H Kimura; K Kobayashi; Y Kashiwabara
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

Review 6.  Drug-resistant M leprae.

Authors:  Paul R Saunderson
Journal:  Clin Dermatol       Date:  2015-10-31       Impact factor: 3.541

7.  Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.

Authors:  Iñaki Comas; Sonia Borrell; Andreas Roetzer; Graham Rose; Bijaya Malla; Midori Kato-Maeda; James Galagan; Stefan Niemann; Sebastien Gagneux
Journal:  Nat Genet       Date:  2011-12-18       Impact factor: 38.330

8.  Leprosy treatment dropout: a systematic review.

Authors:  Régio José Santiago Girão; Nara Lívia Rezende Soares; Juliana Viana Pinheiro; Giuliano da Paz Oliveira; Sionara Melo Figueiredo de Carvalho; Luiz Carlos de Abreu; Vitor E Valenti; Fernando Luiz Affonso Fonseca
Journal:  Int Arch Med       Date:  2013-08-30

9.  Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15.

Authors:  E Cambau; P Saunderson; M Matsuoka; S T Cole; M Kai; P Suffys; P S Rosa; D Williams; U D Gupta; M Lavania; N Cardona-Castro; Y Miyamoto; D Hagge; A Srikantam; W Hongseng; A Indropo; V Vissa; R C Johnson; B Cauchoix; V K Pannikar; E A W D Cooreman; V R R Pemmaraju; L Gillini
Journal:  Clin Microbiol Infect       Date:  2018-03-01       Impact factor: 8.067

10.  Emergence and Transmission of Drug-/Multidrug-resistant Mycobacterium leprae in a Former Leprosy Colony in the Brazilian Amazon.

Authors:  Patrícia S Rosa; Helena R S D'Espindula; Ana C L Melo; Amanda N B Fontes; Amanda J Finardi; Andréa F F Belone; Beatriz G C Sartori; Carla A A Pires; Cleverson T Soares; Flávio B Marques; Francisco J D Branco; Ida M F D Baptista; Lázara M Trino; Luciana R V Fachin; Marília B Xavier; Marcos C Floriano; Somei Ura; Suzana M Diório; Wladimir F B Delanina; Milton O Moraes; Marcos C L Virmond; Philip N Suffys; Marcelo T Mira
Journal:  Clin Infect Dis       Date:  2020-05-06       Impact factor: 9.079
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  3 in total

1.  Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan.

Authors:  Elaine Silva Nascimento Andrade; Jurema Guerrieri Brandão; Juliana Souza da Silva; Carmelita Ribeiro Filha Coriolano; Patricia Sammarco Rosa; Milton Ozório Moraes; Cynthia de Oliveira Ferreira; Ciro Martins Gomes; Wildo Navegantes de Araújo
Journal:  Antimicrob Agents Chemother       Date:  2022-04-18       Impact factor: 5.938

2.  Leprosy in wild chimpanzees.

Authors:  Benjamin Mubemba; Charlotte Avanzi; Kamilla Pleh; Ariane Düx; Elena Bersacola; Joana Bessa; Marina Ramon; Kimberley J Hockings; Sonja Metzger; Livia V Patrono; Jenny E Jaffe; Andrej Benjak; Camille Bonneaud; Philippe Busso; Emmanuel Couacy-Hymann; Moussa Gado; Sebastien Gagneux; Roch C Johnson; Mamoudou Kodio; Joshua Lynton-Jenkins; Irina Morozova; Kerstin Mätz-Rensing; Aissa Regalla; Abílio R Said; Verena J Schuenemann; Samba O Sow; John S Spencer; Markus Ulrich; Hyacinthe Zoubi; Stewart T Cole; Roman M Wittig; Sebastien Calvignac-Spencer; Fabian H Leendertz
Journal:  Nature       Date:  2021-10-13       Impact factor: 49.962

3.  Molecular Surveillance of Antimicrobial Resistance of Mycobacterium leprae from Leprosy Patients in Zhejiang Province, China.

Authors:  Ying Shi; Wenming Kong; Haiqin Jiang; Wenyue Zhang; Chen Wang; Limei Wu; Yunliang Shen; Qiang Yao; Hongsheng Wang
Journal:  Infect Drug Resist       Date:  2022-07-27       Impact factor: 4.177
  3 in total

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