Literature DB >> 32340540

Combinatorial therapy of sirolimus and heparin by nanocarrier inhibits restenosis after balloon angioplasty ex vivo.

Jayesh Betala1, Sooneon Bae1, Eugene M Langan2, Martine LaBerge1, Jeoung Soo Lee1.   

Abstract

Aim: To develop poly(lactide-co-glycolide)-graft-polyethylenimine (PgP) as a dual drug-delivery carrier for sirolimus (SR) and heparin (Hep) to inhibit restenosis after balloon angioplasty. Materials & methods: SR was loaded in the hydrophobic core and negatively charged Hep complexed with the positively charged hydrophilic shell of PgP. SR- and Hep-loaded PgP was tested on rat aortic smooth muscle cells in vitro and injured porcine coronary arteries after balloon angioplasty ex vivo. Results & conclusion: SR and Hep loading efficiency in PgP were approximately 37 and 82%, respectively. SR- and Hep-loaded PgP treatment decreased smooth muscle cell proliferation up to 14 days post-treatment and decreased proliferation, collagen deposition and neointimal thickness and increased patency in porcine coronary arteries after balloon angioplasty ex vivo.

Entities:  

Keywords:  balloon angioplasty; cationic polymeric micelle nanoparticle; combination therapy; drug-eluting balloon; drug-eluting stents; ex vivo; heparin; nanotechnology; restenosis; sirolimus

Mesh：

Substances：

Year:  2020        PMID： 32340540      PMCID： PMC7466912          DOI： 10.2217/nnm-2020-0028

Source DB:  PubMed          Journal:  Nanomedicine (Lond)        ISSN： 1743-5889            Impact factor:   5.307


  52 in total

1.  Intramural delivery of Sirolimus prevents vascular remodeling following balloon injury.

Authors:  Michael Buerke; Markus Guckenbiehl; Hansjörg Schwertz; Ute Buerke; Michael Hilker; Herbert Platsch; Joachim Richert; Sabine Bomm; Guy A Zimmerman; Stephan Lindemann; Ursula Mueller-Werdan; Karl Werdan; Harald Darius; Andrew S Weyrich
Journal:  Biochim Biophys Acta       Date:  2006-05-19

2.  Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model.

Authors:  T Suzuki; G Kopia; S Hayashi ; L R Bailey; G Llanos; R Wilensky; B D Klugherz; G Papandreou; P Narayan; M B Leon; A C Yeung; F Tio; P S Tsao; R Falotico; A J Carter
Journal:  Circulation       Date:  2001-09-04       Impact factor: 29.690

3.  TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors.

Authors:  Vijay A Sethuraman; You Han Bae
Journal:  J Control Release       Date:  2006-12-13       Impact factor: 9.776

4.  Increased synthetic phenotype behavior of smooth muscle cells in response to in vitro balloon angioplasty injury model.

Authors:  K Bethany Acampora; Jiro Nagatomi; Eugene M Langan; Martine LaBerge
Journal:  Ann Vasc Surg       Date:  2009-09-24       Impact factor: 1.466

5.  Sirolimus-loaded stealth colloidal systems attenuate neointimal hyperplasia after balloon injury: a comparison of phospholipid micelles and liposomes.

Authors:  Azadeh Haeri; Saeed Sadeghian; Shahram Rabbani; Maryam Sotoudeh Anvari; Afsaneh Lavasanifar; Mohsen Amini; Simin Dadashzadeh
Journal:  Int J Pharm       Date:  2013-07-16       Impact factor: 5.875

6.  A coronary porcine organ culture system for studies of postangioplasty cell proliferation.

Authors:  R Voisard; V Jensch; R Baur; M Höher; V Hombach
Journal:  Coron Artery Dis       Date:  1995-08       Impact factor: 1.439

7.  A cationic amphiphilic co-polymer as a carrier of nucleic acid nanoparticles (Nanps) for controlled gene silencing, immunostimulation, and biodistribution.

Authors:  Justin R Halman; Ki-Taek Kim; So-Jung Gwak; Richard Pace; M Brittany Johnson; Morgan R Chandler; Lauren Rackley; Mathias Viard; Ian Marriott; Jeoung Soo Lee; Kirill A Afonin
Journal:  Nanomedicine       Date:  2019-10-25       Impact factor: 5.307

Review 8.  The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.

Authors:  Eleonore Fröhlich
Journal:  Int J Nanomedicine       Date:  2012-11-02

9.  Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization.

Authors:  Alice Polchi; Alessandro Magini; Jarosław Mazuryk; Brunella Tancini; Jacek Gapiński; Adam Patkowski; Stefano Giovagnoli; Carla Emiliani
Journal:  Nanomaterials (Basel)       Date:  2016-05-09       Impact factor: 5.076

10.  Physicochemical stability and transfection efficiency of cationic amphiphilic copolymer/pDNA polyplexes for spinal cord injury repair.

Authors:  So-Jung Gwak; Christian Macks; Sooneon Bae; Noah Cecil; Jeoung Soo Lee
Journal:  Sci Rep       Date:  2017-09-12       Impact factor: 4.379
View more
  1 in total

Review 1.  Nanotechnology for cardiovascular diseases.

Authors:  Qinqin Hu; Zheyan Fang; Junbo Ge; Hua Li
Journal:  Innovation (Camb)       Date:  2022-02-02
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.