Literature DB >> 3234043

A new application of in situ hybridization: detection of numerical and structural chromosome aberrations with a combination centromeric-telomeric DNA probe.

H van Dekken1, J G Bauman.   

Abstract

Fluorescent in situ hybridization provides a fast method for detection of specific nucleic acid sequences. We have used high-resolution, single-color fluorescent in situ hybridization with a combination centromeric-telomeric DNA probe, specific for chromosome 1, to investigate the feasibility of simultaneous assessment of numerical and structural chromosome aberrations. The K562 leukemia cell line served as a model.

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Year:  1988        PMID： 3234043     DOI： 10.1159/000132622

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  7 in total

1.  Identification and characterization of normal length nonfluorescent Y chromosomes: cytogenetic analysis, southern hybridization and non-isotopic in situ hybridization.

Authors:  F Speleman; B Van der Auwera; K Mangelschots; M Vercruyssen; T Raap; J Wiegant; M Craen; J Leroy
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

Review 2.  Interphase cytogenetics.

Authors:  C S Herrington; J O McGee
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

3.  Mapping small DNA sequences by fluorescence in situ hybridization directly on banded metaphase chromosomes.

Authors:  Y S Fan; L M Davis; T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  Chromosome in situ suppression hybridisation in human male meiosis.

Authors:  A S Goldman; M A Hultén
Journal:  J Med Genet       Date:  1992-02       Impact factor: 6.318

5.  Two-color hybridization with high complexity chromosome-specific probes and a degenerate alpha satellite probe DNA allows unambiguous discrimination between symmetrical and asymmetrical translocations.

Authors:  H U Weier; J N Lucas; M Poggensee; R Segraves; D Pinkel; J W Gray
Journal:  Chromosoma       Date:  1991-07       Impact factor: 4.316

6.  A human alpha satellite DNA subset specific for chromosome 12.

Authors:  A Baldini; M Rocchi; N Archidiacono; O J Miller; D A Miller
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

Review 7.  Spatial analysis of intranuclear human repetitive DNA regions by in situ hybridization and digital fluorescence microscopy.

Authors:  H van Dekken; R Hulspas
Journal:  Histochem J       Date:  1993-03
  7 in total

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