Siân Bentley1, Jane C Davies2,3, Siobhán B Carr2, Ian M Balfour-Lynn2. 1. Department of Pharmacy, Royal Brompton Hospital, London, UK. 2. Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK. 3. NHLI Imperial College, London, UK.
Abstract
OBJECTIVE: To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis. METHODS: Retrospective case review. RESULTS: There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. prolificans. Treatment duration: median 5 months (range: 5-18 m). In no patient was eradication achieved, with the follow-up range being 6 months to 4 years. Effect on lung function was variable but encouraging. No adverse effects were reported, one child had transient elevation of liver enzymes. CONCLUSIONS: While the combination therapy was well tolerated, it was unsuccessful at eradication.
OBJECTIVE: To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis. METHODS: Retrospective case review. RESULTS: There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. prolificans. Treatment duration: median 5 months (range: 5-18 m). In no patient was eradication achieved, with the follow-up range being 6 months to 4 years. Effect on lung function was variable but encouraging. No adverse effects were reported, one child had transient elevation of liver enzymes. CONCLUSIONS: While the combination therapy was well tolerated, it was unsuccessful at eradication.