OBJECTIVES: A wide range of potential psychosocial, biological, genetic and environmental factors may interact with each other in determining suicidal behaviours. The aim of this study was to evaluate several biological parameters referred to the complete blood count values in 259 suicide attempters (SA) and 164 non-suicide attempters (control group), according to the lethality of suicidal behaviour. METHODS: After attempting suicide, subjects were admitted to the emergency ward of the IRCCS Ospedale Policlinico San Martino and later to the section of Psychiatry from 1 January 2014 to 31 June 2019. Socio-demographic and clinical characteristics, as well as blood cells, were collected. RESULTS: Individuals with high-lethality suicide attempts had a higher number of neutrophils, mean platelet volume, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lower number of lymphocytes relative to both those with low-lethality suicide attempts and control group. After regression analysis, only the mean platelet volume and platelet to lymphocyte ratio resulted associated with a high-lethality suicide attempt (HLSA). CONCLUSIONS: Our findings provide potential and useful peripheral biological markers able to help clinicians in understanding the complex phenomenon of suicide. However, further studies are needed to confirm the present findings.
OBJECTIVES: A wide range of potential psychosocial, biological, genetic and environmental factors may interact with each other in determining suicidal behaviours. The aim of this study was to evaluate several biological parameters referred to the complete blood count values in 259 suicide attempters (SA) and 164 non-suicide attempters (control group), according to the lethality of suicidal behaviour. METHODS: After attempting suicide, subjects were admitted to the emergency ward of the IRCCS Ospedale Policlinico San Martino and later to the section of Psychiatry from 1 January 2014 to 31 June 2019. Socio-demographic and clinical characteristics, as well as blood cells, were collected. RESULTS: Individuals with high-lethality suicide attempts had a higher number of neutrophils, mean platelet volume, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lower number of lymphocytes relative to both those with low-lethality suicide attempts and control group. After regression analysis, only the mean platelet volume and platelet to lymphocyte ratio resulted associated with a high-lethality suicide attempt (HLSA). CONCLUSIONS: Our findings provide potential and useful peripheral biological markers able to help clinicians in understanding the complex phenomenon of suicide. However, further studies are needed to confirm the present findings.
Authors: Oshin Miranda; Peihao Fan; Xiguang Qi; Zeshui Yu; Jian Ying; Haohan Wang; David A Brent; Jonathan C Silverstein; Yu Chen; Lirong Wang Journal: J Pers Med Date: 2022-03-24
Authors: Laura Fusar-Poli; Antimo Natale; Andrea Amerio; Patriciu Cimpoesu; Pietro Grimaldi Filioli; Eugenio Aguglia; Mario Amore; Gianluca Serafini; Andrea Aguglia Journal: Brain Sci Date: 2021-01-06
Authors: A Costanza; A Amerio; A Aguglia; G Serafini; M Amore; R Hasler; J Ambrosetti; G Bondolfi; G Sampogna; I Berardelli; A Fiorillo; M Pompili; K D Nguyen Journal: Neurosci Biobehav Rev Date: 2022-03-12 Impact factor: 9.052
Authors: Alma Delia Genis-Mendoza; Diana María Dionisio-García; Thelma Beatriz Gonzalez-Castro; Carlos Alfonso Tovilla-Zaráte; Isela Esther Juárez-Rojop; María Lilia López-Narváez; Rosa Giannina Castillo-Avila; Humberto Nicolini Journal: Front Psychiatry Date: 2022-06-10 Impact factor: 5.435