Literature DB >> 32337766

Should kidney allografts from old donors be allocated only to old recipients?

Caner Süsal1, Gizem Kumru1, Bernd Döhler1, Christian Morath2, Marije Baas3, Jens Lutz4, Christian Unterrainer1, Wolfgang Arns5, Olivier Aubert6, Christoph Bara7, Andres Beiras-Fernandez8, Georg A Böhmig9, Claudia Bösmüller10, Fritz Diekmann11, Philipp Dutkowski12, Ingeborg Hauser13, Christophe Legendre6, Vladimir J Lozanovski14, Arianeb Mehrabi14, Anette Melk15, Thomas Minor16, Thomas F Mueller17, Przemyslaw Pisarski18, Lionel Rostaing19, Peter Schemmer20, Stefan Schneeberger9, Vedat Schwenger21, Claudia Sommerer2, Burkhard Tönshoff22, Richard Viebahn23, Ondrej Viklicky24, Rolf Weimer25, Karl-Heinz Weiss26, Martin Zeier2, Stela Živčić-Ćosić27, Uwe Heemann28.   

Abstract

In several deceased donor kidney allocation systems, organs from elderly donors are allocated primarily to elderly recipients. The Eurotransplant Senior Program (ESP) was implemented in 1999, and since then, especially in Europe, the use of organs from elderly donors has steadily increased. The proportion of ≥60-year-old donors reported to the Collaborative Transplant Study (CTS) by European centers has doubled, from 21% in 2000-2001 to 42% in 2016-2017. Therefore, in the era of organ shortage it is a matter of debate whether kidney organs from elderly donors should only be allocated to elderly recipients or whether <65-year-old recipients can also benefit from these generally as "marginal" categorized organs. To discuss this issue, a European Consensus Meeting was organized by the CTS on April 12, 2018, in Heidelberg, in which 36 experts participated. Based on available evidence, it was unanimously concluded that kidney organs from 65- to 74-year-old donors can also be allocated to 55- to 64-year-old recipients, especially if these organs are from donors with no history of hypertension, no increased creatinine, no cerebrovascular death, and no other reasons for defining a marginal donor, such as diabetes or cancer.
© 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  donation; expanded donor pool; kidney clinical; outcome

Year:  2020        PMID: 32337766     DOI: 10.1111/tri.13628

Source DB:  PubMed          Journal:  Transpl Int        ISSN: 0934-0874            Impact factor:   3.782


  4 in total

1.  Impact of the explanting surgeon's impression of donor arteriosclerosis on outcome of kidney transplantations from donors aged ≥65 years.

Authors:  Fabian Echterdiek; Constantin Tilgener; Jürgen Dippon; Daniel Kitterer; Justus Scheder-Bieschin; Gregor Paul; Matthias Ott; Ulrich Humke; Vedat Schwenger; Joerg Latus
Journal:  Langenbecks Arch Surg       Date:  2021-11-26       Impact factor: 3.445

2.  Evaluation of Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program in Comparison to Standard Allocation.

Authors:  Nelly Delali Eklou; Bernd M Jänigen; Przemyslaw Pisarski; Gerd Walz; Johanna Schneider
Journal:  Ann Transplant       Date:  2022-08-16       Impact factor: 1.479

Review 3.  Non-Immunologic Causes of Late Death-Censored Kidney Graft Failure: A Personalized Approach.

Authors:  Claudio Ponticelli; Franco Citterio
Journal:  J Pers Med       Date:  2022-08-01

4.  Editorial: Transplantation of Marginal Organs-Immunological Aspects and Therapeutic Perspectives.

Authors:  Caner Süsal; Thomas Friedrich Mueller; Christophe Legendre; Peter Schemmer
Journal:  Front Immunol       Date:  2020-10-29       Impact factor: 7.561

  4 in total

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