Literature DB >> 3233530

The lack of genotoxicity of sodium fluoride in a battery of cellular tests.

C C Tong1, C A McQueen, S V Brat, G M Williams.   

Abstract

In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assay, adult rat liver epithelial cell/hypoxanthine guanine phosphoribosyl transferase mutation assay, and sister chromatid exchange in two target cell types, human peripheral blood lymphocytes and Chinese hamster ovary cells. Negative findings were made in all assays, indicating that sodium fluoride is not genotoxic in these assays.

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Year:  1988        PMID： 3233530     DOI： 10.1007/bf00119244

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  37 in total

Review 1.  A review of systemic and topical fluorides for the prevention of dental caries.

Authors:  H S Horowitz
Journal:  Community Dent Oral Epidemiol       Date:  1973       Impact factor: 3.383

2.  The effect of fluoride on chromosome aberration and sister-chromatid exchange frequencies in cultured human lymphocytes.

Authors:  E J Thomson; F M Kilanowski; P E Perry
Journal:  Mutat Res       Date:  1985-10       Impact factor: 2.433

3.  Induction of unscheduled DNA synthesis in cultured human oral keratinocytes by sodium fluoride.

Authors:  T Tsutsui; K Ide; H Maizumi
Journal:  Mutat Res       Date:  1984-05       Impact factor: 2.433

4.  Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

Authors:  G M Williams
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

5.  The detection of genotoxic chemicals in the adult rat liver epithelial cell/hypoxanthine-guanine phosphoribosyl transferase (ARL/HGPRT) mutagenesis assay.

Authors:  C Tong; M Fazio; S Telang; G M Williams
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

6.  Evidence for an epigenetic mode of action in organochlorine pesticide hepatocarcinogenicity: a lack of genotoxicity in rat, mouse, and hamster hepatocytes.

Authors:  C J Maslansky; G M Williams
Journal:  J Toxicol Environ Health       Date:  1981 Jul-Aug

7.  Simple differential Giemsa staining of sister chromatids after treatment with photosensitive dyes and exposure to light and the mechanism of staining.

Authors:  K Goto; T Akematsu; H Shimazu; T Sugiyama
Journal:  Chromosoma       Date:  1975-12-10       Impact factor: 4.316

8.  DNA-repair studies with sodium fluoride: comparative evaluation using density gradient ultracentrifugation and autoradiography.

Authors:  J A Skare; T K Wong; B L Evans; D B Cody
Journal:  Mutat Res       Date:  1986-10       Impact factor: 2.433

9.  Definition of conditions for the detection of genotoxic chemicals in the adult rat-liver epithelial cell/hypoxanthine-guanine phosphoribosyl transferase (ARL/HGRPT) mutagenesis assay.

Authors:  C Tong; G M Williams
Journal:  Mutat Res       Date:  1980-02       Impact factor: 2.433

10.  Metal-induced lethality and mutagenesis: possible role of apurinic intermediates.

Authors:  R M Schaaper; R M Koplitz; L K Tkeshelashvili; L A Loeb
Journal:  Mutat Res       Date:  1987-04       Impact factor: 2.433
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  3 in total

1.  Evaluation of mutagenic and cytotoxic effects of sodium fluoride on mammalian cells influenced by an acid environment.

Authors:  D Slamenová; K Ruppová; A Gábelová; L Wsólová
Journal:  Cell Biol Toxicol       Date:  1996-02       Impact factor: 6.691

2.  Genotoxic effects of heavy metals in rat hepatocytes.

Authors:  F Denizeau; M Marion
Journal:  Cell Biol Toxicol       Date:  1989-01       Impact factor: 6.691

3.  Transforming activities of sodium fluoride in cultured Syrian hamster embryo and BALB/3T3 cells.

Authors:  C Lasne; Y P Lu; I Chouroulinkov
Journal:  Cell Biol Toxicol       Date:  1988-09       Impact factor: 6.691
  3 in total

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