Shelly Soffer1, Eyal Klang1, Orit Shimon2, Noy Nachmias3, Rami Eliakim4, Shomron Ben-Horin4, Uri Kopylov4, Yiftach Barash1. 1. Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel; Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; DeepVision Lab, Sheba Medical Center, Tel Hashomer, Israel. 2. Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Department of Anesthesia, Rabin Medical Center, Beilinson Hospital, Petach Tikvah, Israel. 3. Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Departments of Internal Medicine D, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel. 4. Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel.
Abstract
BACKGROUND AND AIMS: Deep learning is an innovative algorithm based on neural networks. Wireless capsule endoscopy (WCE) is considered the criterion standard for detecting small-bowel diseases. Manual examination of WCE is time-consuming and can benefit from automatic detection using artificial intelligence (AI). We aimed to perform a systematic review of the current literature pertaining to deep learning implementation in WCE. METHODS: We conducted a search in PubMed for all original publications on the subject of deep learning applications in WCE published between January 1, 2016 and December 15, 2019. Evaluation of the risk of bias was performed using tailored Quality Assessment of Diagnostic Accuracy Studies-2. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curves were plotted. RESULTS: Of the 45 studies retrieved, 19 studies were included. All studies were retrospective. Deep learning applications for WCE included detection of ulcers, polyps, celiac disease, bleeding, and hookworm. Detection accuracy was above 90% for most studies and diseases. Pooled sensitivity and specificity for ulcer detection were .95 (95% confidence interval [CI], .89-.98) and .94 (95% CI, .90-.96), respectively. Pooled sensitivity and specificity for bleeding or bleeding source were .98 (95% CI, .96-.99) and .99 (95% CI, .97-.99), respectively. CONCLUSIONS: Deep learning has achieved excellent performance for the detection of a range of diseases in WCE. Notwithstanding, current research is based on retrospective studies with a high risk of bias. Thus, future prospective, multicenter studies are necessary for this technology to be implemented in the clinical use of WCE.
BACKGROUND AND AIMS: Deep learning is an innovative algorithm based on neural networks. Wireless capsule endoscopy (WCE) is considered the criterion standard for detecting small-bowel diseases. Manual examination of WCE is time-consuming and can benefit from automatic detection using artificial intelligence (AI). We aimed to perform a systematic review of the current literature pertaining to deep learning implementation in WCE. METHODS: We conducted a search in PubMed for all original publications on the subject of deep learning applications in WCE published between January 1, 2016 and December 15, 2019. Evaluation of the risk of bias was performed using tailored Quality Assessment of Diagnostic Accuracy Studies-2. Pooled sensitivity and specificity were calculated. Summary receiver operating characteristic curves were plotted. RESULTS: Of the 45 studies retrieved, 19 studies were included. All studies were retrospective. Deep learning applications for WCE included detection of ulcers, polyps, celiac disease, bleeding, and hookworm. Detection accuracy was above 90% for most studies and diseases. Pooled sensitivity and specificity for ulcer detection were .95 (95% confidence interval [CI], .89-.98) and .94 (95% CI, .90-.96), respectively. Pooled sensitivity and specificity for bleeding or bleeding source were .98 (95% CI, .96-.99) and .99 (95% CI, .97-.99), respectively. CONCLUSIONS: Deep learning has achieved excellent performance for the detection of a range of diseases in WCE. Notwithstanding, current research is based on retrospective studies with a high risk of bias. Thus, future prospective, multicenter studies are necessary for this technology to be implemented in the clinical use of WCE.
Authors: Jiang Kailin; Jiang Xiaotao; Pan Jinglin; Wen Yi; Huang Yuanchen; Weng Senhui; Lan Shaoyang; Nie Kechao; Zheng Zhihua; Ji Shuling; Liu Peng; Li Peiwu; Liu Fengbin Journal: Front Med (Lausanne) Date: 2021-03-15
Authors: Fredy Nehme; Hemant Goyal; Abhilash Perisetti; Benjamin Tharian; Neil Sharma; Tony C Tham; Rajiv Chhabra Journal: Front Med (Lausanne) Date: 2021-12-23