Yibin Liu1, Chaowei Li1, Chunchun Wu1, Ping Li1, Yunan Su1, Qingshi Chen2. 1. The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzhou, 362000, Fujian, China. 2. The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzhou, 362000, Fujian, China. chenqingshi1986@126.com.
Abstract
PURPOSE: It remains inconclusive whether continuous positive airway pressure (CPAP) therapy can significantly reduce subcutaneous adipose tissue (SAT) in patients with obstructive sleep apnea (OSA). This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the impact of CPAP treatment on SAT in patients with OSA. METHODS: We searched Pubmed, Cochrane, Web of Science, and Embase for RCTs, which investigated the effectiveness of CPAP treatment in reducing SAT among patients with OSA. Following the PRISMA guidelines, we extracted information on the study and patient characteristics, and pre- and post-CPAP measures of SAT. We then calculated the overall effects using the standardized mean difference (SMD) with a 95% confidence interval (CI). RESULTS: A total of 5 RCTs (comprising 153 patients) met inclusion criteria for the meta-analysis. We found that the SAT did not change before and after CPAP treatment in patients with OSA (SMD = - 0.02, 95% CI - 0.25 to 0.2, z = 0.19, p = 0.85). Subgroup analyses indicated that the outcome was not affected by age, CPAP therapy duration, baseline body mass index, and measure utilized. CONCLUSION: This meta-analysis of RCTs suggests that CPAP therapy does not significantly decrease the level of SAT among patients with OSA. Further large-scale, and high-quality randomized controlled trials are needed to better address this issue.
PURPOSE: It remains inconclusive whether continuous positive airway pressure (CPAP) therapy can significantly reduce subcutaneous adipose tissue (SAT) in patients with obstructive sleep apnea (OSA). This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the impact of CPAP treatment on SAT in patients with OSA. METHODS: We searched Pubmed, Cochrane, Web of Science, and Embase for RCTs, which investigated the effectiveness of CPAP treatment in reducing SAT among patients with OSA. Following the PRISMA guidelines, we extracted information on the study and patient characteristics, and pre- and post-CPAP measures of SAT. We then calculated the overall effects using the standardized mean difference (SMD) with a 95% confidence interval (CI). RESULTS: A total of 5 RCTs (comprising 153 patients) met inclusion criteria for the meta-analysis. We found that the SAT did not change before and after CPAP treatment in patients with OSA (SMD = - 0.02, 95% CI - 0.25 to 0.2, z = 0.19, p = 0.85). Subgroup analyses indicated that the outcome was not affected by age, CPAP therapy duration, baseline body mass index, and measure utilized. CONCLUSION: This meta-analysis of RCTs suggests that CPAP therapy does not significantly decrease the level of SAT among patients with OSA. Further large-scale, and high-quality randomized controlled trials are needed to better address this issue.
Authors: Marcel Wächter; Jan W Kantelhardt; Maria R Bonsignore; Izolde Bouloukaki; Pierre Escourrou; Ingo Fietze; Ludger Grote; Damian Korzybski; Carolina Lombardi; Oreste Marrone; Ivana Paranicova; Athanasia Pataka; Silke Ryan; Sophia E Schiza; Pawel Sliwinski; Paschalis Steiropoulos; Johan Verbraecken; Thomas Penzel Journal: J Sleep Res Date: 2019-07-25 Impact factor: 3.981
Authors: Kirsten Bibbins-Domingo; David C Grossman; Susan J Curry; Karina W Davidson; John W Epling; Francisco A R García; Jessica Herzstein; Alex R Kemper; Alex H Krist; Ann E Kurth; C Seth Landefeld; Carol M Mangione; William R Phillips; Maureen G Phipps; Michael P Pignone; Michael Silverstein; Chien-Wen Tseng Journal: JAMA Date: 2017-01-24 Impact factor: 56.272
Authors: Ram A Sharma; Andrew W Varga; Omonigho M Bubu; Elizabeth Pirraglia; Korey Kam; Ankit Parekh; Margaret Wohlleber; Margo D Miller; Andreia Andrade; Clifton Lewis; Samuel Tweardy; Maja Buj; Po L Yau; Reem Sadda; Lisa Mosconi; Yi Li; Tracy Butler; Lidia Glodzik; Els Fieremans; James S Babb; Kaj Blennow; Henrik Zetterberg; Shou E Lu; Sandra G Badia; Sergio Romero; Ivana Rosenzweig; Nadia Gosselin; Girardin Jean-Louis; David M Rapoport; Mony J de Leon; Indu Ayappa; Ricardo S Osorio Journal: Am J Respir Crit Care Med Date: 2018-04-01 Impact factor: 30.528