Diego Santos-García1, Teres de Deus-Fonticoba2, Ester Suárez Castro2, Ángel M Aneiros Díaz2, María J Feal-Painceiras3, Jose M Paz-González3, Carlos García-Sancho3, Silvia Jesús4,5, Pablo Mir4,5, Lluís Planellas6, Juan García-Caldentey7, Nuria Caballol8, Inés Legarda9, Jorge Hernández-Vara10, Isabel González-Aramburu11, María A Ávila-Rivera12, María J Catalán13, Víctor Nogueira14, María Álvarez-Sauco15, Lydia Vela16, Sonia Escalante17, Esther Cubo18, Pilar Sánchez-Alonso19, María G Alonso-Losada20, Nuria López-Ariztegui21, Pablo Martinez-Martin5,22. 1. Section of Neurology, Complejo Hospitalario Universitario de A Coruña (CHUAC), HUAC, C / As Xubias 84, 15006, A Coruña, Spain. diegosangar@yahoo.es. 2. Hospital Arquitecto Marcide y Hospital Naval, Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain. 3. Section of Neurology, Complejo Hospitalario Universitario de A Coruña (CHUAC), HUAC, C / As Xubias 84, 15006, A Coruña, Spain. 4. Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. 5. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. 6. Hospital Clínic de Barcelona, Barcelona, Spain. 7. Centro Neurológico Oms 42, Palma de Mallorca, Spain. 8. Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain. 9. Hospital Universitario Son Espases, Palma de Mallorca, Spain. 10. Hospital Universitario Vall d'Hebron, Barcelona, Spain. 11. Hospital Universitario Marqués de Valdecilla, Santander, Spain. 12. Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Barcelona, Spain. 13. Hospital Universitario Clínico San Carlos, Madrid, Spain. 14. Hospital Da Costa de Burela, Lugo, Spain. 15. Hospital General Universitario de Elche, Elche, Spain. 16. Fundación Hospital de Alcorcón, Madrid, Spain. 17. Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain. 18. Complejo Asistencial Universitario de Burgos, Burgos, Spain. 19. Hospital Universitario Puerta de Hierro, Madrid, Spain. 20. Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain. 21. Complejo Hospitalario de Toledo, Toledo, Spain. 22. Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain.
Abstract
BACKGROUND AND OBJECTIVE: Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson's disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype. METHODS: The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype. RESULTS: Among the 689 PD patients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411-8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206-42.564; p = 0.030). CONCLUSIONS: Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
BACKGROUND AND OBJECTIVE: Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson's disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PDpatients as well as assess its relationship with functional dependency with regard to motor phenotype. METHODS: The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype. RESULTS: Among the 689 PDpatients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411-8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206-42.564; p = 0.030). CONCLUSIONS: Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
Authors: D Santos García; T De Deus Fonticoba; J M Paz González; C Cores Bartolomé; L Valdés Aymerich; J G Muñoz Enríquez; E Suárez; S Jesús; M Aguilar; P Pastor; L L Planellas; M Cosgaya; J García Caldentey; N Caballol; I Legarda; J Hernández Vara; I Cabo; L López Manzanares; I González Aramburu; M A Ávila Rivera; M J Catalán; V Nogueira; V Puente; J M García Moreno; C Borrué; B Solano Vila; M Álvarez Sauco; L Vela; S Escalante; E Cubo; F Carrillo Padilla; J C Martínez Castrillo; P Sánchez Alonso; M G Alonso Losada; N López Ariztegui; I Gastón; J Kulisevsky; M Blázquez Estrada; M Seijo; J Rúiz Martínez; C Valero; M Kurtis; O de Fábregues; J González Ardura; C Ordás; L López Díaz; P Mir; P Martinez-Martin Journal: Parkinsons Dis Date: 2021-05-13
Authors: Diego Santos García; Lucía Naya Ríos; Teresa de Deus Fonticoba; Carlos Cores Bartolomé; Lucía García Roca; Maria Feal Painceiras; Cristina Martínez Miró; Hector Canfield; Silvia Jesús; Miquel Aguilar; Pau Pastor; Marina Cosgaya; Juan García Caldentey; Nuria Caballol; Inés Legarda; Jorge Hernández Vara; Iria Cabo; Lydia López Manzanares; Isabel González Aramburu; María A Ávila Rivera; Víctor Gómez Mayordomo; Víctor Nogueira; Víctor Puente; Julio Dotor; Carmen Borrué; Berta Solano Vila; María Álvarez Sauco; Lydia Vela; Sonia Escalante; Esther Cubo; Francisco Carrillo Padilla; Juan C Martínez Castrillo; Pilar Sánchez Alonso; Maria G Alonso Losada; Nuria López Ariztegui; Itziar Gastón; Jaime Kulisevsky; Marta Blázquez Estrada; Manuel Seijo; Javier Rúiz Martínez; Caridad Valero; Mónica Kurtis; Oriol de Fábregues; Jessica González Ardura; Ruben Alonso Redondo; Carlos Ordás; Luis M López Díaz; Darrian McAfee; Pablo Martinez-Martin; Pablo Mir Journal: Diagnostics (Basel) Date: 2021-12-17