Massimiliano Cantinotti1, Marco Scalese2, Raffaele Giordano3, Nadia Assanta1, Pietro Marchese1, Eliana Franchi1, Cecilia Viacava1, Martin Koestenberger4, Vivek Jani5, Shelby Kutty5. 1. Fondazione CNR-Regione Toscana G. Monasterio, Massa, Italy. 2. Institute of Clinical Physiology (IFC), National Research Institute (CNR), Pisa, Italy. 3. Department of Advanced Biomedical Sciences, Adult and Pediatric Cardiac Surgery, University of Naples Federico II, Naples, Italy. r.giordano81@libero.it. 4. Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria. 5. Taussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, 21205-2196, USA.
Abstract
BACKGROUND: The aim of this study is to compare new pediatric nomograms for clinical parameters from 2D echocardiography. METHODS: 2D pediatric echocardiographic parameters from four recent nomograms were used for statistical analysis. To assess the accuracy of the predictive models from each study, namely multivariate, linear, and nonlinear regression, mean values and 5th and 95th percentiles (μ ± 1.65σ) were calculated. A Z-score calculator was created. RESULTS: Mean values and 5th and 95th percentiles have been provided for a range of BSA (0.15-2.20 m2) for each nomogram assessed in this study. Moreover, plots of Z-scores over the same range of BSA have been generated to assess trends among different studies. For most measurements from the two most recent nomograms, namely Lopez et al. and Cantinotti et al., differences were within a Z-score of 0.5 (Z-score range: 0.001-1.26). Measurements from Sluysmans and Colan and Pettersen et al. were observed to diverge from Lopez et al. at the upper extremities of BSA. Differences among various nomograms emerged at lower extremes of BSA. CONCLUSIONS: The two most recent echocardiographic nomograms were observed to have the most statistically similar ranges of normality. Significant deviations in ranges of normality were observed at extremes of BSA. IMPACT: Echocardiographic nomograms for pediatric age are discordant. Comparison of current pediatric echocardiographic nomograms. A Z-score calculator was created. Clinical relevance of differences among nomograms is highlighted.
BACKGROUND: The aim of this study is to compare new pediatric nomograms for clinical parameters from 2D echocardiography. METHODS: 2D pediatric echocardiographic parameters from four recent nomograms were used for statistical analysis. To assess the accuracy of the predictive models from each study, namely multivariate, linear, and nonlinear regression, mean values and 5th and 95th percentiles (μ ± 1.65σ) were calculated. A Z-score calculator was created. RESULTS: Mean values and 5th and 95th percentiles have been provided for a range of BSA (0.15-2.20 m2) for each nomogram assessed in this study. Moreover, plots of Z-scores over the same range of BSA have been generated to assess trends among different studies. For most measurements from the two most recent nomograms, namely Lopez et al. and Cantinotti et al., differences were within a Z-score of 0.5 (Z-score range: 0.001-1.26). Measurements from Sluysmans and Colan and Pettersen et al. were observed to diverge from Lopez et al. at the upper extremities of BSA. Differences among various nomograms emerged at lower extremes of BSA. CONCLUSIONS: The two most recent echocardiographic nomograms were observed to have the most statistically similar ranges of normality. Significant deviations in ranges of normality were observed at extremes of BSA. IMPACT: Echocardiographic nomograms for pediatric age are discordant. Comparison of current pediatric echocardiographic nomograms. A Z-score calculator was created. Clinical relevance of differences among nomograms is highlighted.
Authors: Leo Lopez; Peter C Frommelt; Steven D Colan; Felicia L Trachtenberg; Russell Gongwer; Mario Stylianou; Aarti Bhat; Kristin M Burns; Meryl S Cohen; Andreea Dragulescu; Lindsay R Freud; Michele A Frommelt; Irene D Lytrivi; Joseph Mahgerefteh; Brian W McCrindle; Ricardo Pignatelli; Ashwin Prakash; Ritu Sachdeva; Jonathan H Soslow; Christopher Spurney; Carolyn L Taylor; Poonam P Thankavel; Thor Thorsson; Justin T Tretter; Luciana T Young; L LuAnn Minich Journal: J Am Soc Echocardiogr Date: 2020-11-12 Impact factor: 5.251
Authors: Sabrina Schweintzger; Stefan Kurath-Koller; Ante Burmas; Gernot Grangl; Andrea Fandl; Nathalie Noessler; Alexander Avian; Andreas Gamillscheg; Philippe Chouvarine; Georg Hansmann; Martin Koestenberger Journal: Front Cardiovasc Med Date: 2022-07-14