Sarah A Lyons1, Michael Clausen2, André C Knulst3, Barbara K Ballmer-Weber4, Montserrat Fernandez-Rivas5, Laura Barreales6, Christian Bieli7, Ruta Dubakiene8, Cristina Fernandez-Perez6, Monika Jedrzejczak-Czechowicz9, Marek L Kowalski9, Tanya Kralimarkova10, Ischa Kummeling11, Tihomir B Mustakov10, Nikolaos G Papadopoulos12, Todor A Popov13, Paraskevi Xepapadaki14, Paco M J Welsing15, James Potts11, E N Clare Mills16, Ronald van Ree17, Peter G J Burney11, Thuy-My Le3. 1. Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address: s.a.lyons-2@umcutrecht.nl. 2. Children's Hospital, Landspitali University Hospital, Reykjavik, Iceland. 3. Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. 4. Allergy Unit, Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland; Faculty of Medicine, University of Zürich, Zürich, Switzerland; Clinic for Dermatology and Allergology, Kantonsspital St Gallen, St Gallen, Switzerland. 5. Allergy Department, Hospital Clinico San Carlos, IdISSC, ARADyAL, Madrid, Spain. 6. Servicio de Medicina Preventiva, Epidemiology Unit, Hospital Clinico San Carlos, UCM, IdISSC, Madrid, Spain. 7. Department of Paediatric Pulmonology, University Children's Hospital, Zürich, Switzerland. 8. Medical Faculty, Vilnius University, Vilnius, Lithuania. 9. Department of Allergy and Immunology, Medical University of Lodz, Lodz, Poland. 10. Clinical Centre of Allergology of the Alexandrovska Hospital, Medical University of Sofia, Sofia, Bulgaria. 11. National Heart and Lung Institute, Imperial College London, London, United Kingdom. 12. Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece; Division of Infection, Immunity and Respiratory Medicine, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom. 13. University Hospital Sv. Ivan Rilski, Sofia, Bulgaria. 14. Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece. 15. Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands. 16. Division of Infection, Immunity and Respiratory Medicine, Manchester Institute of Biotechnology & Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom. 17. Department of Experimental Immunology and Department of Otorhinolaryngology, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Abstract
BACKGROUND: For adults, prevalence estimates of food sensitization (FS) and food allergy (FA) have been obtained in a standardized manner across Europe. For children, such estimates are lacking. OBJECTIVES: To determine the prevalence of self-reported FA, FS, probable FA (symptoms plus IgE sensitization), and challenge-confirmed FA in European school-age children. METHODS: Data on self-reported FA were collected through a screening questionnaire sent to a random sample of the general population of 7- to 10-year-old children in 8 European centers in phase I of the EuroPrevall study. Data on FS and probable FA were obtained in phase II, comprising an extensive questionnaire on reactions to 24 commonly implicated foods, and serology testing. Food challenge was performed in phase III. RESULTS: Prevalence (95% CI) of self-reported FA ranged from 6.5% (5.4-7.6) in Athens to 24.6% (22.8-26.5) in Lodz; prevalence of FS ranged from 11.0% (9.7-12.3) in Reykjavik to 28.7% (26.9-30.6) in Zurich; and prevalence of probable FA ranged from 1.9% (0.8-3.5) in Reykjavik to 5.6% (3.6-8.1) in Lodz. In all centers, most food-sensitized subjects had primary (non-cross-reactive) FS. However, FS due to birch pollen related cross-reactivity was also common in Central-Northern Europe. Probable FA to milk and egg occurred frequently throughout Europe; to fish and shrimp mainly in the Mediterranean and Reykjavik. Peach, kiwi, and peanut were prominent sources of plant FA in most countries, along with notably hazelnut, apple, carrot, and celery in Central-Northern Europe and lentils and walnut in the Mediterranean. CONCLUSIONS: There are large geograhical differences in the prevalence of FS and FA in school-age children across Europe. Both primary and cross-reactive FS and FA occur frequently.
BACKGROUND: For adults, prevalence estimates of food sensitization (FS) and food allergy (FA) have been obtained in a standardized manner across Europe. For children, such estimates are lacking. OBJECTIVES: To determine the prevalence of self-reported FA, FS, probable FA (symptoms plus IgE sensitization), and challenge-confirmed FA in European school-age children. METHODS: Data on self-reported FA were collected through a screening questionnaire sent to a random sample of the general population of 7- to 10-year-old children in 8 European centers in phase I of the EuroPrevall study. Data on FS and probable FA were obtained in phase II, comprising an extensive questionnaire on reactions to 24 commonly implicated foods, and serology testing. Food challenge was performed in phase III. RESULTS: Prevalence (95% CI) of self-reported FA ranged from 6.5% (5.4-7.6) in Athens to 24.6% (22.8-26.5) in Lodz; prevalence of FS ranged from 11.0% (9.7-12.3) in Reykjavik to 28.7% (26.9-30.6) in Zurich; and prevalence of probable FA ranged from 1.9% (0.8-3.5) in Reykjavik to 5.6% (3.6-8.1) in Lodz. In all centers, most food-sensitized subjects had primary (non-cross-reactive) FS. However, FS due to birch pollen related cross-reactivity was also common in Central-Northern Europe. Probable FA to milk and egg occurred frequently throughout Europe; to fish and shrimp mainly in the Mediterranean and Reykjavik. Peach, kiwi, and peanut were prominent sources of plant FA in most countries, along with notably hazelnut, apple, carrot, and celery in Central-Northern Europe and lentils and walnut in the Mediterranean. CONCLUSIONS: There are large geograhical differences in the prevalence of FS and FA in school-age children across Europe. Both primary and cross-reactive FS and FA occur frequently.
Authors: Lin Ching-Wei; Tsai Yi-Fen; Su Yu-Tsun; Yu Hong-Ren; Li Hsing-Jung; Hung Chih-Hsing; Liu Li-Fan; Tsai Hui-Ju; Wang Jiu-Yao Journal: World Allergy Organ J Date: 2022-06-24 Impact factor: 5.516
Authors: Stephen C Dreskin; Stef J Koppelman; Sandra Andorf; Kari C Nadeau; Anjeli Kalra; Werner Braun; Surendra S Negi; Xueni Chen; Catherine H Schein Journal: J Allergy Clin Immunol Date: 2020-11-18 Impact factor: 10.793
Authors: Sarah A Lyons; André C Knulst; Peter G J Burney; Montserrat Fernandez-Rivas; Barbara K Ballmer-Weber; Laura Barreales; Christian Bieli; Michael Clausen; Ruta Dubakiene; Cristina Fernandez-Perez; Monika Jedrzejczak-Czechowicz; Marek L Kowalski; Ischa Kummeling; Tanya Kralimarkova; Tihomir B Mustakov; Harmieke van Os-Medendorp; Nikolaos G Papadopoulos; Todor A Popov; James Potts; Serge A Versteeg; Paraskevi Xepapadaki; Paco M J Welsing; Clare Mills; Ronald van Ree; Thuy-My Le Journal: Allergy Date: 2020-09-24 Impact factor: 13.146
Authors: Elissa M Abrams; Elinor Simons; Jennifer Gerdts; Orla Nazarko; Beatrice Povolo; Jennifer L P Protudjer Journal: BMC Public Health Date: 2020-08-01 Impact factor: 3.295