Po-An Lin1, Chia-Yi Lee2,3, Fu-Chin Huang1,4, Jing-Yang Huang5, Jia-Horung Hung1,4,6, Shun-Fa Yang5,7. 1. Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan, Taiwan. 2. Department of Ophthalmology, Show Chwan Memorial Hospital , Changhua, Taiwan. 3. Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology , Tainan, Taiwan. 4. Department of Ophthalmology, College of Medicine, National Cheng Kung University , Tainan, Taiwan. 5. Department of Medical Research, Chung Shan Medical University Hospital , Taichung, Taiwan. 6. Institute of Clinical Medicine, College of Medicine, National Cheng Kung University , Tainan, Taiwan. 7. Institute of Medicine, Chung Shan Medical University , Taichung, Taiwan.
Abstract
PURPOSE: To determine the trends in epidemiological data in patients with neovascular glaucoma (NVG) in Taiwan. METHODS: The data were obtained from the 2016 version of the Longitudinal Health Insurance Database, which contains data on two million randomly sampled patients. Patients with NVG diagnostic codes were enrolled in this study, after which we separated the study population according to different time periods. The demographic data, systemic and ocular comorbidities and treatments that were applied to manage NVG were collected from the database. RESULTS: The overall age-standardized prevalence was 52.48 per 100,000 individuals, and the age-standardized incidence was 4.33 per 100,000 person-years in patients with NVG. In general, men had a higher prevalence and incidence, and the incidence was observed to fluctuate. The patients with the highest educational levels accounted for less than 5% of the NVG patients, and the patients with the highest income levels accounted for less than 15% of the NVG patients. Systemic comorbidities in NVG patients, especially metabolic syndrome, were observed to increase. The percentage of the patients receiving anti-vascular endothelial growth factor treatments increased by more than two-fold after 2008, whereas reductions in trabeculectomy and cyclodestruction procedures were observed. CONCLUSION: The prevalence of NVG was observed to increase in men, and the incidence fluctuated during the study period. Furthermore, the systemic comorbidities, and the use of anti-vascular endothelial growth factor treatment increased; the latter may be associated with a decrease in the use of incisional glaucoma surgery for NVG in recent years.
PURPOSE: To determine the trends in epidemiological data in patients with neovascular glaucoma (NVG) in Taiwan. METHODS: The data were obtained from the 2016 version of the Longitudinal Health Insurance Database, which contains data on two million randomly sampled patients. Patients with NVG diagnostic codes were enrolled in this study, after which we separated the study population according to different time periods. The demographic data, systemic and ocular comorbidities and treatments that were applied to manage NVG were collected from the database. RESULTS: The overall age-standardized prevalence was 52.48 per 100,000 individuals, and the age-standardized incidence was 4.33 per 100,000 person-years in patients with NVG. In general, men had a higher prevalence and incidence, and the incidence was observed to fluctuate. The patients with the highest educational levels accounted for less than 5% of the NVG patients, and the patients with the highest income levels accounted for less than 15% of the NVG patients. Systemic comorbidities in NVG patients, especially metabolic syndrome, were observed to increase. The percentage of the patients receiving anti-vascular endothelial growth factor treatments increased by more than two-fold after 2008, whereas reductions in trabeculectomy and cyclodestruction procedures were observed. CONCLUSION: The prevalence of NVG was observed to increase in men, and the incidence fluctuated during the study period. Furthermore, the systemic comorbidities, and the use of anti-vascular endothelial growth factor treatment increased; the latter may be associated with a decrease in the use of incisional glaucoma surgery for NVG in recent years.
Entities:
Keywords:
Neovascular glaucoma; anti-VEGF; epidemiology; sex
Authors: Charles M Medert; Catherine Q Sun; Elizabeth Vanner; Richard K Parrish; Sarah R Wellik Journal: BMC Ophthalmol Date: 2021-12-20 Impact factor: 2.209