BACKGROUND: Atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) are 2 separate entities that coexist in a significant proportion of patients. In patients with CTI ablation of AFL, the decision to hold anticoagulation often becomes an issue. OBJECTIVES: This study aimed to describe the incidence of the development of AF after CTI ablation in patients without a history of AF and to identify the risk predictors of the occurrence of AF. METHODS: The present study included 120 consecutive patients (106 men; mean age 68 ± 12 years) who underwent radiofrequency catheter ablation (RFCA) of typical AFL since 2010. Patients with a history of AF before RFCA were excluded. The P-wave and QRS morphology, characteristics, and duration were evaluated by 12-lead electrocardiography the day after ablation. RESULTS: During 3.6 ± 2.6 years of follow-up after RFCA, 49 patients (41%) developed new-onset AF. A univariate analysis revealed that the presence of fragmented QRS (fQRS) complexes (hazard ratio [HR], 4.63; 95% confidence interval [CI] 2.31-9.29; P < .001) and advanced interatrial block (IAB), defined as P-wave duration > 120 ms and biphasic morphology in the inferior leads (HR 4.44; 95% CI 2.45-8.01; P < .001), were predictors of new-onset AF. A multivariate analysis revealed that fQRS complexes (HR 3.35; 95% CI 1.58-7.10; P = .002) and advanced IAB (HR 2.64; 95% CI 1.38-5.07; P < .004) were independent predictors. CONCLUSION: The present study indicated that new-onset AF developed in a significant proportion of patients undergoing AFL ablation. The presence of fQRS complexes and advanced IAB were predictors of new-onset AF.
BACKGROUND:Atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) are 2 separate entities that coexist in a significant proportion of patients. In patients with CTI ablation of AFL, the decision to hold anticoagulation often becomes an issue. OBJECTIVES: This study aimed to describe the incidence of the development of AF after CTI ablation in patients without a history of AF and to identify the risk predictors of the occurrence of AF. METHODS: The present study included 120 consecutive patients (106 men; mean age 68 ± 12 years) who underwent radiofrequency catheter ablation (RFCA) of typical AFL since 2010. Patients with a history of AF before RFCA were excluded. The P-wave and QRS morphology, characteristics, and duration were evaluated by 12-lead electrocardiography the day after ablation. RESULTS: During 3.6 ± 2.6 years of follow-up after RFCA, 49 patients (41%) developed new-onset AF. A univariate analysis revealed that the presence of fragmented QRS (fQRS) complexes (hazard ratio [HR], 4.63; 95% confidence interval [CI] 2.31-9.29; P < .001) and advanced interatrial block (IAB), defined as P-wave duration > 120 ms and biphasic morphology in the inferior leads (HR 4.44; 95% CI 2.45-8.01; P < .001), were predictors of new-onset AF. A multivariate analysis revealed that fQRS complexes (HR 3.35; 95% CI 1.58-7.10; P = .002) and advanced IAB (HR 2.64; 95% CI 1.38-5.07; P < .004) were independent predictors. CONCLUSION: The present study indicated that new-onset AF developed in a significant proportion of patients undergoing AFL ablation. The presence of fQRS complexes and advanced IAB were predictors of new-onset AF.