| Literature DB >> 32325168 |
Marcus de Melo Teixeira1, Maria Emilia Cattana2, Daniel R Matute3, José F Muñoz4, Alicia Arechavala5, Kristin Isbell3, Rafael Schipper6, Gabriela Santiso5, Fernanda Tracogna7, María de Los Ángeles Sosa8, Norma Cech9, Primavera Alvarado10, Laura Barreto11, Yone Chacón12, Juana Ortellado13, Cleoni Mendes de Lima14, Marilene Rodrigues Chang15, Gustavo Niño-Vega16, Maria Aparecida Shikanai Yasuda17, Maria Sueli Soares Felipe18, Ricardo Negroni5, Christina A Cuomo4, Bridget Barker19, Gustavo Giusiano20.
Abstract
Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely reported in the Gran Chaco ecosystem. The disease is caused by different species from the genus Paracoccidioides, which are all endemic to South and Central America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across South America, with particular focus on isolates from Argentina and Paraguay. The de novo sequenced isolates were compared with publicly available genomes. Phylogenetics and population genomics revealed that PCM in Argentina and Paraguay is caused by three distinct Paracoccidioides genotypes, P. brasiliensis (S1a and S1b) and P. restrepiensis (PS3). P. brasiliensis S1a isolates from Argentina are frequently associated with chronic forms of the disease. Our results suggest the existence of extensive molecular polymorphism among Paracoccidioides species, and provide a framework to begin to dissect the connection between genotypic differences in the pathogen and the clinical outcomes of the disease.Entities:
Keywords: Gran Chaco; Paracoccidioides; Phylogenomics; Population genetics
Year: 2020 PMID： 32325168 PMCID： PMC7385733 DOI： 10.1016/j.fgb.2020.103395
Source DB: PubMed Journal: Fungal Genet Biol ISSN： 1087-1845 Impact factor: 3.495