Ellie Maghami1, Nofisat Ismaila2, Adriana Alvarez3, Rebecca Chernock4, Umamaheswar Duvvuri5, Jessica Geiger3, Neil Gross6, Bruce Haughey7, Doru Paul8, Cristina Rodriguez9, David Sher10, Hilda E Stambuk11, John Waldron12, Matt Witek13, James Caudell14. 1. City of Hope, Duarte, CA. 2. American Society of Clinical Oncology, Alexandria, VA. 3. Cleveland Clinic Foundation, Cleveland, OH. 4. Washington University School of Medicine, St Louis, MO. 5. University of Pittsburgh, Pittsburgh, PA. 6. MD Anderson Cancer Center, Houston, TX. 7. Advent Health Medical Group, Otolaryngology, Head and Neck Surgery, Celebration, FL, and University of South Florida, Tampa, FL. 8. Weill Cornell Medical College, New York, NY. 9. University of Washington, Seattle, WA. 10. University of Texas Southwestern, Dallas, TX. 11. Memorial Sloan Kettering Cancer Center, New York, NY. 12. Princess Margaret Cancer Centre, Toronto, Ontario, Canada. 13. University of Wisconsin School of Medicine and Public Health, Madison, WI. 14. Moffitt Cancer Center, Tampa, FL.
Abstract
PURPOSE: To provide evidence-based recommendations to practicing physicians and other health care providers on the diagnosis and management of squamous cell carcinoma of unknown primary in the head and neck (SCCUP). METHODS: The American Society of Clinical Oncology convened an Expert Panel of medical oncology, surgery, radiation oncology, radiology, pathology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2008 through 2019. Outcomes of interest included survival, local and regional disease control, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS: The literature search identified 100 relevant studies to inform the evidence base for this guideline. Four main clinical questions were addressed, which included subquestions on preoperative evaluations, surgical diagnostic and therapeutic procedures, appropriate pathology techniques, and adjuvant therapy. RECOMMENDATIONS: Evidence-based recommendations were developed to address preoperative evaluation for patients with a neck mass, surgical diagnostic and therapeutic procedures, appropriate treatment options in unilateral versus bilateral SCCUP.Additional information is available at www.asco.org/head-neck-cancer-guidelines.
PURPOSE: To provide evidence-based recommendations to practicing physicians and other health care providers on the diagnosis and management of squamous cell carcinoma of unknown primary in the head and neck (SCCUP). METHODS: The American Society of Clinical Oncology convened an Expert Panel of medical oncology, surgery, radiation oncology, radiology, pathology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2008 through 2019. Outcomes of interest included survival, local and regional disease control, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS: The literature search identified 100 relevant studies to inform the evidence base for this guideline. Four main clinical questions were addressed, which included subquestions on preoperative evaluations, surgical diagnostic and therapeutic procedures, appropriate pathology techniques, and adjuvant therapy. RECOMMENDATIONS: Evidence-based recommendations were developed to address preoperative evaluation for patients with a neck mass, surgical diagnostic and therapeutic procedures, appropriate treatment options in unilateral versus bilateral SCCUP.Additional information is available at www.asco.org/head-neck-cancer-guidelines.
Authors: Andressa Silva de Freitas; Guilherme Maia Zica; Mariana Salles; Ana Catarina Alves E Silva; Thiago Huaytalla Silva; Fernando Luiz Dias; Izabella Costa Santos Journal: Int Arch Otorhinolaryngol Date: 2021-11-03
Authors: Matthias Balk; Robin Rupp; Konstantinos Mantsopoulos; Matti Sievert; Magdalena Gostian; Moritz Allner; Philipp Grundtner; Markus Eckstein; Heinrich Iro; Markus Hecht; Antoniu-Oreste Gostian Journal: J Clin Med Date: 2022-05-10 Impact factor: 4.964
Authors: Flora Yan; Hannah M Knochelmann; Patrick F Morgan; John M Kaczmar; David M Neskey; Evan M Graboyes; Shaun A Nguyen; Besim Ogretmen; Anand K Sharma; Terry A Day Journal: Cancers (Basel) Date: 2020-06-11 Impact factor: 6.639
Authors: Francisco J Civantos; Jan B Vermorken; Jatin P Shah; Alessandra Rinaldo; Carlos Suárez; Luiz P Kowalski; Juan P Rodrigo; Kerry Olsen; Primoz Strojan; Antti A Mäkitie; Robert P Takes; Remco de Bree; June Corry; Vinidh Paleri; Ashok R Shaha; Dana M Hartl; William Mendenhall; Cesare Piazza; Michael Hinni; K Thomas Robbins; Ng Wai Tong; Alvaro Sanabria; Andres Coca-Pelaz; Johannes A Langendijk; Juan Hernandez-Prera; Alfio Ferlito Journal: Front Oncol Date: 2020-11-10 Impact factor: 6.244