J-P Lin1,2, Y-J Zhao3, Q-L He4, H-K Hao5, Y-T Tian6, B-B Zou7, L-X Jiang8, W Lin9, Y B Zhou10, Z Li11, Y-C Xu12, G Zhao13, F-Q Xue14, S-L Li15, W-H Fu16, Y-X Li7, X-J Zhou17, Y Li18, Z-G Zhu19, J-P Chen20, Z-K Xu21, L-H Cai22, E Li23, H-L Li24, J-W Xie1,2, C-M Huang1,2, P Li1,2, J-X Lin1,2, C-H Zheng1,2. 1. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China. 2. Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China. 3. Department of Gastrointestinal Surgery, West District of First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. 4. Department of Gastrointestinal Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, China. 5. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China. 6. Department of Pancreatic and Gastric Surgery, National Cancer Centre/National Clinical Research Centre for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 7. Department of Gastrointestinal Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China. 8. Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital, Yantai, China. 9. Department of Gastrointestinal Surgery and Gastrointestinal Surgery Research Institute, Affiliated Hospital of Putian University, Putian, China. 10. Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China. 11. Department of General Surgery, Henan Cancer Hospital, Zhengzhou, China. 12. Department of Gastrointestinal Surgery, Fujian Medicine University Teaching Hospital, First Hospital of PuTian, Putian, China. 13. Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, China. 14. Department of Gastrointestinal Surgery, Provincial Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China. 15. Department of Gastrointestinal Surgery, Second People's Hospital of Liaocheng, Liaocheng, China. 16. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China. 17. Department of Gastroenterological Surgery, First Affiliated Hospital of Soochow University, Suzhou, China. 18. Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. 19. Department of Gastrointestinal Surgery, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. 20. Department of Gastrointestinal Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China. 21. Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 22. Department of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China. 23. Department of Gastrointestinal Surgery, Meizhou People's Hospital, Meizhou, China. 24. Department of Gastrointestinal Surgery, Second Affiliated Hospital, Nanchang University, Nanchang, China.
Abstract
BACKGROUND: The aim of this study was to evaluate whether adjuvant chemotherapy is associated with improved survival in patients with resectable gastric neuroendocrine carcinomas (G-NECs) or mixed adenoneuroendocrine carcinomas (G-MANECs). METHODS: The study included patients with G-NECs or G-MANECs who underwent surgery in one of 21 centres in China between 2004 and 2016. Propensity score matching analysis was used to reduce selection bias, and overall survival (OS) in different treatment groups was estimated by the Kaplan-Meier method. RESULTS: In total, 804 patients with resectable G-NECs or G-MANECs were included, of whom 490 (60·9 per cent) received adjuvant chemotherapy. After propensity score matching, OS in the chemotherapy group was similar to that in the no-chemotherapy group. Among patients with G-NECs, survival in the fluorouracil (5-FU)-based chemotherapy group and the non-5-FU-based chemotherapy group was similar to that in the no-chemotherapy group. Similarly, etoposide plus cisplatin or irinotecan plus cisplatin was not associated with better OS in patients with G-NECs. Among patients with G-MANECs, OS in the non-5-FU-based chemotherapy group was worse than that in the no-chemotherapy group. Patients with G-MANECs did not have better OS when platinum-based chemotherapy was used. CONCLUSION: There was no survival benefit in patients who received adjuvant chemotherapy for G-NECs or G-MANECs.
BACKGROUND: The aim of this study was to evaluate whether adjuvant chemotherapy is associated with improved survival in patients with resectable gastric neuroendocrine carcinomas (G-NECs) or mixed adenoneuroendocrine carcinomas (G-MANECs). METHODS: The study included patients with G-NECs or G-MANECs who underwent surgery in one of 21 centres in China between 2004 and 2016. Propensity score matching analysis was used to reduce selection bias, and overall survival (OS) in different treatment groups was estimated by the Kaplan-Meier method. RESULTS: In total, 804 patients with resectable G-NECs or G-MANECs were included, of whom 490 (60·9 per cent) received adjuvant chemotherapy. After propensity score matching, OS in the chemotherapy group was similar to that in the no-chemotherapy group. Among patients with G-NECs, survival in the fluorouracil (5-FU)-based chemotherapy group and the non-5-FU-based chemotherapy group was similar to that in the no-chemotherapy group. Similarly, etoposide plus cisplatin or irinotecan plus cisplatin was not associated with better OS in patients with G-NECs. Among patients with G-MANECs, OS in the non-5-FU-based chemotherapy group was worse than that in the no-chemotherapy group. Patients with G-MANECs did not have better OS when platinum-based chemotherapy was used. CONCLUSION: There was no survival benefit in patients who received adjuvant chemotherapy for G-NECs or G-MANECs.
Authors: Elettra Merola; Andrea Michielan; Umberto Rozzanigo; Marco Erini; Sandro Sferrazza; Stefano Marcucci; Chiara Sartori; Chiara Trentin; Giovanni de Pretis; Franca Chierichetti Journal: World J Gastrointest Surg Date: 2022-02-27
Authors: Marcus Fernando Kodama Pertille Ramos; Marina Alessandra Pereira; Arthur Youssif Mota Arabi; Melissa Mello Mazepa; Andre Roncon Dias; Ulysses Ribeiro; Bruno Zilberstein; Sergio Carlos Nahas Journal: Med Sci (Basel) Date: 2021-06-25