Literature DB >> 32321698

Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts.

Joseph A Ioppolo1, Rikki A Nezich2, Kirsty L Richardson3, Laurence Morandeau4, Peter J Leedman3, Roger I Price2.   

Abstract

The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AlF-PSMA-11; Ga-PSMA-11; PSMA-1007; Preclinical; Prostate cancer

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Year:  2020        PMID： 32321698     DOI： 10.1016/j.apradiso.2020.109164

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  2 in total

1.  Intra-individual dynamic comparison of 18F-PSMA-11 and 68Ga-PSMA-11 in LNCaP xenograft bearing mice.

Authors:  Sarah Piron; Jeroen Verhoeven; Benedicte Descamps; Ken Kersemans; Kathia De Man; Nick Van Laeken; Leen Pieters; Anne Vral; Christian Vanhove; Filip De Vos
Journal:  Sci Rep       Date:  2020-12-03       Impact factor: 4.379

2.  Preclinical comparative study of [18F]AlF-PSMA-11 and [18F]PSMA-1007 in varying PSMA expressing tumors.

Authors:  Sarah Piron; Jeroen Verhoeven; Jan Courtyn; Ken Kersemans; Benedicte Descamps; Leen Pieters; Anne Vral; Christian Vanhove; Filip De Vos
Journal:  Sci Rep       Date:  2022-09-21       Impact factor: 4.996
  2 in total

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