Literature DB >> 32320301

Direct KRAS inhibition: progress, challenges, and a glimpse into the future.

Dimitra Grapsa1, Konstantinos Syrigos1.   

Abstract

Entities:  

Keywords:  Direct targeting; KRAS; KRAS(G12C); inhibitor; treatment response

Mesh：

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Year:  2020        PMID： 32320301     DOI： 10.1080/14737140.2020.1760093

Source DB:  PubMed          Journal:  Expert Rev Anticancer Ther        ISSN： 1473-7140            Impact factor:   4.512


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  2 in total

1.  Identification of Synergistic Drug Combinations to Target KRAS-Driven Chemoradioresistant Cancers Utilizing Tumoroid Models of Colorectal Adenocarcinoma and Recurrent Glioblastoma.

Authors:  Kshama Gupta; Jeremy C Jones; Virginea De Araujo Farias; Yuri Mackeyev; Pankaj K Singh; Alfredo Quiñones-Hinojosa; Sunil Krishnan
Journal:  Front Oncol       Date:  2022-05-18       Impact factor: 5.738

2.  Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models.

Authors:  Long Chen; Jing Zhang; Xinjing Wang; Yu Li; Lu Zhou; Xiongxiong Lu; Guoqiang Dong; Chunquan Sheng
Journal:  Acta Pharm Sin B       Date:  2021-07-19       Impact factor: 11.413
  2 in total

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