BACKGROUND: Oral squamous cell carcinoma (OSCC) occurs in different subsites within the oral cavity. Our goal was to investigate the epidemiological features of OSCC with relation to age and subsite. METHODS: Retrospective review of all patients treated for OSCC in a tertiary care center between 2000 and 2018. RESULTS: A total of 360 patients were included. Five age groups were defined: 0 to 30, 31 to 45, 46 to 60, 61 to 75, and 76+. In the 0 to 30 and 31 to 45 groups, 94.6% of tumors originated in the oral tongue compared to 87%, 66%, and 61% in the 46 to 60, 61 to 75, and 76+ groups, respectively (P < .001). A higher proportion of oral tongue SCC (OTSCC) was found in nonsmokers (76% vs 62%, P = .02). In nonsmokers aged 0 to 60, 97.9% had OTSCC compared to 67.5% in the 61+ groups (P < .001). CONCLUSIONS: OSCC in young nonsmokers originates primarily in the tongue. The etiology of OTSCC in young patients may be different than other OSCC subsites and not related to smoking.
BACKGROUND:Oral squamous cell carcinoma (OSCC) occurs in different subsites within the oral cavity. Our goal was to investigate the epidemiological features of OSCC with relation to age and subsite. METHODS: Retrospective review of all patients treated for OSCC in a tertiary care center between 2000 and 2018. RESULTS: A total of 360 patients were included. Five age groups were defined: 0 to 30, 31 to 45, 46 to 60, 61 to 75, and 76+. In the 0 to 30 and 31 to 45 groups, 94.6% of tumors originated in the oral tongue compared to 87%, 66%, and 61% in the 46 to 60, 61 to 75, and 76+ groups, respectively (P < .001). A higher proportion of oral tongue SCC (OTSCC) was found in nonsmokers (76% vs 62%, P = .02). In nonsmokers aged 0 to 60, 97.9% had OTSCC compared to 67.5% in the 61+ groups (P < .001). CONCLUSIONS: OSCC in young nonsmokers originates primarily in the tongue. The etiology of OTSCC in young patients may be different than other OSCC subsites and not related to smoking.
Authors: Xiaobin Ren; Lin Jing Song; Mingzhu Zhang; Wanli Zhang; Ken Lin; Hongbing He Journal: Evid Based Complement Alternat Med Date: 2022-07-07 Impact factor: 2.650
Authors: Luca Calabrese; Maria Eleonora Bizzoca; Roberto Grigolato; Fausto Antonio Maffini; Marta Tagliabue; Rosa Negro; Stefania Leuci; Michele Davide Mignogna; Lorenzo Lo Muzio Journal: Life (Basel) Date: 2020-09-12