Literature DB >> 32320077

Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover.

Xupeng Hong1, Jianming Hu1.   

Abstract

Current therapies can suppress the replication of hepatitis B virus (HBV) but cannot clear chronic HBV infection, which afflicts hundreds of millions worldwide. HBV persistence is sustained by the viral covalently closed circular DNA (cccDNA), an episome in the nucleus of infected hepatocytes. cccDNA is refractory to current therapies and its clearance is the holy grail for HBV cure. However, it has been difficult to monitor the fate of cccDNA in the liver directly. The current study takes a novel approach to this critical issue by monitoring the dynamic change in the genetic composition of the serum HBV RNA, which appears to reflect the dynamics of intrahepatic cccDNA turnover.
© 2020 Wiley Periodicals LLC.

Entities:  

Keywords:  anti-hepatitis B virus antivirals; antiviral agents; cccDNA; hepatitis B virus; infection; nucleoside analogs; persistent infection; reverse transcriptase; serum HBV RNA

Mesh：

Substances：

Year:  2020        PMID： 32320077      PMCID： PMC7379877          DOI： 10.1002/jmv.25925

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  9 in total

1.  Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication.

Authors:  William R Addison; Kathie-Anne Walters; Winnie W S Wong; John S Wilson; Danuta Madej; Lawrence D Jewell; D Lorne J Tyrrell
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

Review 2.  Hepadnavirus Genome Replication and Persistence.

Authors:  Jianming Hu; Christoph Seeger
Journal:  Cold Spring Harb Perspect Med       Date:  2015-07-01       Impact factor: 6.915

3.  Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids.

Authors:  Stefan F Wieland; Angelina Eustaquio; Christina Whitten-Bauer; Bryan Boyd; Francis V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-01       Impact factor: 11.205

4.  Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.

Authors:  G Moraleda; J Saputelli; C E Aldrich; D Averett; L Condreay; W S Mason
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

5.  Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis.

Authors:  Y Zhu; T Yamamoto; J Cullen; J Saputelli; C E Aldrich; D S Miller; S Litwin; P A Furman; A R Jilbert; W S Mason
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

6.  Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.

Authors:  Bettina Werle-Lapostolle; Scott Bowden; Stephen Locarnini; Karsten Wursthorn; Jorg Petersen; George Lau; Christian Trepo; Patrick Marcellin; Zachary Goodman; William E Delaney; Shelly Xiong; Carol L Brosgart; Shan-Shan Chen; Craig S Gibbs; Fabien Zoulim
Journal:  Gastroenterology       Date:  2004-06       Impact factor: 22.682

Review 7.  Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection.

Authors:  Shi Liu; Bin Zhou; Juan D Valdes; Jian Sun; Haitao Guo
Journal:  Hepatology       Date:  2019-03-20       Impact factor: 17.425

Review 8.  Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application.

Authors:  Jianming Hu; Kuancheng Liu
Journal:  Viruses       Date:  2017-03-21       Impact factor: 5.048

9.  Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature-Mutation in Treated Chronic Hepatitis B Patients.

Authors:  Qi Huang; Bin Zhou; Dawei Cai; Yuhua Zong; Yaobo Wu; Shi Liu; Alexandre Mercier; Haitao Guo; Jinlin Hou; Richard Colonno; Jian Sun
Journal:  Hepatology       Date:  2020-12-01       Impact factor: 17.425
  9 in total

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