| Literature DB >> 32320074 |
Igor C Fontana1,2, Aline R Zimmer1, Andreia S Rocha2, Grace Gosmann1, Diogo O Souza2,3, Mychael V Lourenco4, Sergio T Ferreira4,5, Eduardo R Zimmer2,6,7.
Abstract
Amyloid-β (Aβ) dysmetabolism is tightly associated with pathological processes in Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to plaque formation, Aβ aggregates into non-fibrillar soluble oligomers (AβOs). Soluble AβOs have been extensively studied for their synaptotoxic and neurotoxic properties. In this review, we discuss physicochemical properties of AβOs and their impact on different brain cell types in AD. Additionally, we summarize three decades of studies with AβOs, providing a compelling bulk of evidence regarding cell-specific mechanisms of toxicity. Cellular models may lead us to a deeper understanding of the detrimental effects of AβOs in neurons and glial cells, putatively shedding light on the development of innovative therapies for AD.Entities:
Keywords: Alzheimer's disease; amyloid-beta; cell cultures; oligomers
Year: 2020 PMID： 32320074 DOI： 10.1111/jnc.15030
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372