| Literature DB >> 32320035 |
Todd A Pezzi1, David L Schwartz1,2, Katherine M W Pisters3, Abdallah S R Mohamed1, James W Welsh1, Joe Y Chang1, Zhongxing Liao1, Saumil J Gandhi1, Lauren A Byers3, Bruce D Minsky1, Clifton D Fuller1, Stephen G Chun1.
Abstract
Importance: Small cell lung cancer (SCLC) is an aggressive neoplasm requiring rapid access to subspecialized multidisciplinary care. For this reason, insurance coverage such as Medicaid may be associated with oncologic outcomes in this disproportionately economically vulnerable population. With Medicaid expansion under the Affordable Care Act, it is important to understand outcomes associated with Medicaid coverage among patients with SCLC. Objective: To determine the association of Medicaid coverage with survival compared with other insurance statuses. Design, Setting, and Participants: This cohort study included adult patients with limited-stage (LS) and extensive-stage (ES) SCLC in the US National Cancer Database from 2004 to 2013. Data were analyzed in January 2019. Main Outcomes and Measures: Patients were analyzed with respect to insurance status. Associations of insurance status with survival were interrogated with univariate analyses, multivariable analyses, and propensity score matching.Entities:
Mesh:
Year: 2020 PMID: 32320035 PMCID: PMC7177199 DOI: 10.1001/jamanetworkopen.2020.3277
Source DB: PubMed Journal: JAMA Netw Open ISSN: 2574-3805
Baseline Characteristics of Patients With Small Cell Lung Cancer in the US National Cancer Database 2004 to 2013
| Characteristic | Patients with small cell lung cancer, No. (%) | ||
|---|---|---|---|
| Limited stage | Extensive stage | Total | |
| Sample size | 70 247 (38.6) | 109 479 (60.2) | 181 784 (100.0) |
| Facility type | |||
| Community cancer program | 10 342 (14.8) | 16 757 (15.4) | 27 381 (15.1) |
| Comprehensive community cancer program | 37 178 (53.1) | 56 672 (51.9) | 94 860 (52.4) |
| Academic or research program | 17 675 (25.2) | 28 245 (25.9) | 46 566 (25.7) |
| Integrated network cancer program | 4719 (6.7) | 7296 (6.7) | 12 130 (6.7) |
| Other specified types of cancer programs | 93 (0.1) | 145 (0.1) | 238 (0.1) |
| Insurance status | |||
| No insurance | 2266 (3.2) | 4806 (4.4) | 7145 (3.9) |
| Private or managed care | 20 055 (28.5) | 30 610 (28.0) | 51 173 (28.2) |
| Medicaid | 4437 (6.3) | 8092 (7.4) | 12 692 (7.0) |
| Medicare | 40 984 (58.3) | 62 151 (56.8) | 104 300 (57.4) |
| Other | 2505 (3.6) | 3820 (3.5) | 6474 (3.6) |
| Sex | |||
| Male | 31 381 (44.7) | 56 352 (51.5) | 88 653 (48.8) |
| Female | 38 866 (55.3) | 53 127 (48.5) | 93 131 (51.2) |
| Age, median (interquartile range), y | 68 (60-75) | 67 (60-75) | |
| Ethnicity | |||
| White | 63 081 (89.8) | 98 884 (90.3) | 163 758 (90.1) |
| Black | 5495 (7.8) | 8015 (7.3) | 13 702 (7.5) |
| Other | 1133 (1.6) | 1706 (1.6) | 2894 (1.6) |
| Unknown | 538 (0.8) | 874 (0.8) | 1430 (0.8) |
| Charlson-Deyo Comorbidity Index score | |||
| 0 | 40 800 (58.1) | 61 366 (56.1) | 103 458 (56.9) |
| 1 | 20 332 (28.9) | 32 331 (29.5) | 53 176 (29.3) |
| 2 | 9115 (13.0) | 15 782 (14.4) | 25 150 (13.8) |
| T category | |||
| T1 | 13 341 (19.0) | 9925 (9.1) | 23 495 (12.9) |
| T2 | 18 028 (25.7) | 20 643 (18.9) | 38 997 (21.5) |
| T3 | 7201 (10.3) | 10 442 (9.5) | 17 788 (9.8) |
| T4 | 18 248 (26.0) | 37 142 (33.9) | 55 665 (30.6) |
| TX | 13 429 (19.1) | 31 327 (28.6) | 45 839 (25.2) |
| N category | |||
| N0 | 13 615 (19.4) | 12 652 (11.6) | 27 149 (14.9) |
| N1 | 6683 (9.5) | 7794 (7.1) | 14 609 (8.0) |
| N2 | 30 563 (43.5) | 47 070 (43.0) | 78 188 (43.0) |
| N3 | 9040 (12.9) | 19 711 (18.0) | 28 910 (15.9) |
| NX | 10 346 (14.7) | 22 252 (20.3) | 32 928 (18.1) |
Multivariable Analysis of Factors Associated With Survival Among Patients With Limited-Stage Small Cell Lung Cancer
| Variable | HR (95% CI) | |
|---|---|---|
| Facility type | ||
| Community cancer program | 1 [Reference] | |
| Comprehensive community cancer program | 0.93 (0.90-0.95) | <.001 |
| Academic or research program | 0.85 (0.83-0.87) | <.001 |
| Integrated network cancer program | 0.91 (0.87-0.94) | <.001 |
| Other specified types of cancer programs | 0.57 (0.44-0.74) | <.001 |
| Insurance status | ||
| No insurance | 1 [Reference] | |
| Private or managed care | 0.82 (0.78-0.87) | <.001 |
| Medicaid | 1.06 (1.00-1.12) | .06 |
| Medicare | 0.92 (0.88-0.97) | .002 |
| Other | 0.91 (0.86-0.98) | .01 |
| Sex | ||
| Male | 1 [Reference] | |
| Female | 0.85 (0.84-0.87) | <.001 |
| Age (continuous) | 1.02 (1.02-1.03) | <.001 |
| Charlson-Deyo Comorbidity Index score | ||
| 0 | 1 [Reference] | |
| 1 | 1.16 (1.14-1.18) | <.001 |
| 2 | 1.42 (1.39-1.46) | <.001 |
| T category | ||
| T1 | 1 [Reference] | |
| T2 | 1.33 (1.30-1.37) | <.001 |
| T3 | 1.57 (1.52-1.62) | <.001 |
| T4 | 1.78 (1.73-1.82) | <.001 |
| TX | 1.31 (1.27-1.35) | <.001 |
| N category | ||
| N0 | 1 [Reference] | |
| N1 | 1.31 (1.26-1.35) | <.001 |
| N2 | 1.62 (1.58-1.66) | <.001 |
| N3 | 1.86 (1.80-1.92) | <.001 |
| NX | 1.62 (1.57-1.68) | <.001 |
| Chemotherapy | ||
| None | 1 [Reference] | |
| Single-agent or multiagent chemotherapy | 0.62 (0.61-0.64) | <.001 |
| Chemotherapy contraindicated | 1.87 (1.76-2.00) | <.001 |
| Recommended, but not administered | 1.08 (1.04-1.13) | <.001 |
| Unknown | 0.58 (0.52-0.65) | <.001 |
| Radiation therapy | ||
| Not received | 1 [Reference] | |
| Received | 0.61 (0.60-0.63) | <.001 |
| Unknown | 0.52 (0.47-0.59) | <.001 |
Abbreviation: HR, hazard ratio.
Multivariable Analysis of Factors Associated With Survival Among Patients With Extensive-Stage Small Cell Lung Cancer
| Variable | HR (95% CI) | |
|---|---|---|
| Facility type | ||
| Community cancer program | 1 [Reference] | |
| Comprehensive community cancer program | 1.00 (0.98-1.02) | .94 |
| Academic or research program | 0.93 (0.91-0.95) | <.001 |
| Integrated network cancer program | 0.96 (0.93-0.99) | .004 |
| Other specified types of cancer programs | 0.95 (0.80-1.14) | .60 |
| Insurance status | ||
| No insurance | 1 [Reference] | |
| Private or managed care | 0.86 (0.83-0.89) | <.001 |
| Medicaid | 1.00 (0.96-1.03) | .78 |
| Medicare | 0.94 (0.91-0.97) | <.001 |
| Other | 0.91 (0.87-0.95) | <.001 |
| Sex | ||
| Male | 1 [Reference] | |
| Female | 0.87 (0.86-0.88) | <.001 |
| Age (continuous) | 1.01 (1.01-1.01) | <.001 |
| Charlson-Deyo Comorbidity Index score | ||
| 0 | 1 [Reference] | |
| 1 | 1.17 (1.15-1.18) | <.001 |
| 2 | 1.40 (1.37-1.42) | <.001 |
| T category | ||
| T1 | 1 [Reference] | |
| T2 | 1.15 (1.12-1.18) | <.001 |
| T3 | 1.18 (1.15-1.22) | <.001 |
| T4 | 1.26 (1.23-1.29) | <.001 |
| TX | 1.21 (1.18-1.24) | <.001 |
| N category | ||
| N0 | 1 [Reference] | |
| N1 | 1.06 (1.03-1.09) | <.001 |
| N2 | 1.19 (1.16-1.21) | <.001 |
| N3 | 1.20 (1.17-1.23) | <.001 |
| NX | 1.16 (1.13-1.19) | <.001 |
| Chemotherapy | ||
| None | 1 [Reference] | |
| Single-agent or multiagent chemotherapy | 0.40 (0.39-0.40) | <.001 |
| Chemotherapy contraindicated | 1.63 (1.56-1.69) | <.001 |
| Recommended, but not administered | 1.08 (1.06-1.11) | <.001 |
| Unknown | 0.48 (0.43-0.54) | <.001 |
| Radiation therapy | ||
| Not received | 1 [Reference] | |
| Received | 0.78 (0.77-0.79) | <.001 |
| Unknown | 0.54 (0.49-0.60) | <.001 |
Abbreviation: HR, hazard ratio.
Figure. Kaplan-Meier Curves for Overall Survival of Patients With Small Cell Lung Cancer After Propensity Score Matching
Graphs show overall survival curves for propensity score–matched cohorts of patients with limited-stage small cell lung cancer (A) and extensive-stage small cell lung cancer (B).
Cox Multivariable Analysis of Propensity Matched Sample for Patients With Limited-Stage and Extensive-Stage Small Cell Lung Cancer
| Variable | HR (95% CI) | |
|---|---|---|
| Patients with limited-stage small cell lung cancer | ||
| Facility type | ||
| Community cancer program | 1 [Reference] | |
| Comprehensive community cancer program | 0.93 (0.85-1.02) | .14 |
| Academic or research program | 0.82 (0.74-0.91) | <.001 |
| Integrated network cancer program | 0.84 (0.72-0.97) | .02 |
| Other specified types of cancer programs | 0.58 (0.22-1.55) | .28 |
| Insurance status | ||
| None | 1 [Reference] | |
| Medicaid | 1.05 (0.98-1.12) | .17 |
| Sex | ||
| Male | 1 [Reference] | |
| Female | 0.81 (0.76-0.87) | <.001 |
| Age, y | ||
| 18-50 | 1 [Reference] | |
| 51-64 | 1.17 (1.07-1.28) | .001 |
| 65-75 | 1.22 (1.06-1.41) | .01 |
| 76-90 | 2.20 (1.79-2.69) | <.001 |
| Charlson-Deyo Comorbidity Index score | ||
| 0 | 1 [Reference] | |
| 1 | 1.16 (1.08-1.25) | <.001 |
| 2 | 1.48 (1.32-1.65) | <.001 |
| T category | ||
| T1 | 1 [Reference] | |
| T2 | 1.30 (1.15-1.47) | <.001 |
| T3 | 1.63 (1.42-1.86) | <.001 |
| T4 | 1.71 (1.52-1.92) | <.001 |
| TX | 1.38 (1.20-1.59) | <.001 |
| N category | ||
| N0 | 1 [Reference] | |
| N1 | 1.32 (1.15-1.52) | <.001 |
| N2 | 1.50 (1.36-1.66) | <.001 |
| N3 | 1.71 (1.52-1.92) | <.001 |
| NX | 1.65 (1.43-1.90) | <.001 |
| Chemotherapy | ||
| None | 1 [Reference] | |
| Yes | 0.66 (0.60-0.73) | <.001 |
| Radiation therapy | ||
| Not received | [Reference] | |
| Received | 0.59 (0.55-0.64) | <.001 |
| Patients with extensive-stage small cell lung cancer | ||
| Facility type | ||
| Community cancer program | 1 [Reference] | |
| Comprehensive community cancer program | 1.03 (0.97-1.10) | .31 |
| Academic or research program | 0.93 (0.87-0.99) | .03 |
| Integrated network cancer program | 0.89 (0.81-0.98) | .02 |
| Other specified types of cancer programs | 1.85 (0.77-4.46) | .17 |
| Insurance status | ||
| None | 1 [Reference] | |
| Medicaid | 1.00 (0.96-1.04) | .92 |
| Sex | ||
| Male | 1 [Reference] | |
| Female | 0.88 (0.85-0.92) | <.001 |
| Age, y | ||
| 18-50 | 1 [Reference] | |
| 51-64 | 1.05 (0.99-1.11) | .10 |
| 65-75 | 1.05 (0.96-1.16) | .27 |
| 76-90 | 1.02 (0.90-1.17) | .76 |
| Charlson-Deyo Comorbidity Index score | ||
| 0 | 1 [Reference] | |
| 1 | 1.10 (1.05-1.16) | <.001 |
| 2 | 1.35 (1.26-1.44) | <.001 |
| T category | ||
| T1 | 1 [Reference] | |
| T2 | 1.10 (1.00-1.21) | .04 |
| T3 | 1.14 (1.03-1.26) | .01 |
| T4 | 1.20 (1.11-1.31) | <.001 |
| TX | 1.25 (1.14-1.37) | <.001 |
| N category | ||
| N0 | 1 [Reference] | |
| N1 | 1.08 (0.98-1.20) | .12 |
| N2 | 1.16 (1.09-1.25) | <.001 |
| N3 | 1.19 (1.10-1.28) | <.001 |
| NX | 1.10 (1.02-1.19) | .02 |
| Chemotherapy | ||
| None | 1 [Reference] | |
| Yes | 0.39 (0.38-0.41) | <.001 |
| Radiation therapy | ||
| Not received | 1 [Reference] | |
| Received | 0.77 (0.74-0.80) | <.001 |
Abbreviation: HR, hazard ratio.