[Reaserch Progress on Non-Coding RNA in Multiple Myeloma --Review].

It is found that non-coding RNAs (ncRNA) plays an important role in the development and treatment of multiple myeloma (MM). For example, some microRNAs (miRNAs) can regulate gene expression, affect autophagy, apoptosis and other physiological and pathological processes, affect synthesis of protein, etc., thus providing a basis for diagnosis, treatment and prognosis of MM evaluation. Long-chain non-coding RNA (Long noncoding RNA, lncRNA) can participate in cell differentiation, bind transcription factors to modify histones, specifically regulate the genome, etc., thus providing potential therapeutic targets for MM patients. While circular RNA (CircRNA) possesses post-transcriptional regulation on function and gene expression, thereby inhibiting the cell activity and proliferation of MM, further inducing apoptosis. In this reviews the functional characteristics of different non-coding RNAs and their research progress in multiple myeloma are summarized briefly.