Literature DB >> 32319175

Evaluation of the efficacy of topical sucralfate on healing haemorrhoidectomy incision wounds and reducing pain severity: A randomised clinical trial.

Amir K Vejdan1, Maliheh Khosravi2, Zahra Amirian3, Maryam Daneshmand4, Bahman Babak4, Khorashdi Samira4, Seifi Azin4, Salehitorabi Kosar4, Khodadadzadeh Razie4.   

Abstract

The healing of haemorrhoidectomy wounds is a main concern of surgeons and patients. Various modalities can improve the quality of wound care after surgery. Antibiotics and topical agents, such as solutions and ointments, have been evaluated. The current research investigates the effects of sucralfate ointment on wound healing (epithelialisation) and postoperative pain after open haemorrhoidectomy. This trial involves two groups of randomly collected patients (n = 40) who underwent open haemorrhoidectomy surgery by the Milligan-Morgan method. A 10% topical sucralfate ointment was applied to the investigated group's wounds, while the control group patients used Vaseline as a placebo. The present work measured the two outcomes as follows: pain severity by a Visual Analogues Scale (VAS) score and epithelialisation by a surgeon's visual inspection. During the postoperative phase, the mean VAS was 3.70 for the investigated group and 6.90 for the control group. On the average, the completion of epithelialisation for the investigated group was on day 13 as opposed to day 20 for the control group. The topical application of sucralfate ointment on post-haemorrhoidectomy wound is an effective method for the promotion of healing, also lessens the severity of pain, and reduces the need for analgesics.
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Entities:  

Keywords:  epithelialisation; haemorrhoidectomy; sucralfate; wound healing

Mesh:

Substances:

Year:  2020        PMID: 32319175     DOI: 10.1111/iwj.13369

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  3 in total

1.  The effect of sucralfate-containing ointment on quality of life in people with symptoms associated with haemorrhoidal disease and its complications: the results of the EMOCARE survey.

Authors:  Corrado Giua; Luigi Minerba; Antonio Piras; Nicolina Floris; Flora Romano; Group Sifac
Journal:  Acta Biomed       Date:  2021-02-04

2.  Sucralfate enemas reduce the oxidative tissue damage and preserves the contents of E-cadherin and ?-catenin in colonic mucosa without fecal stream.

Authors:  Daniela Tiemi Sato; Fabio Guilherme Campos; Paulo Gustavo Kotze; Roberta Laís Santos Mendonça; Danilo Toshio Kanno; José Aires Pereira; Carlos Augusto Real Martinez
Journal:  Acta Cir Bras       Date:  2021-11-29       Impact factor: 1.388

Review 3.  Strategies to Reduce Post-Hemorrhoidectomy Pain: A Systematic Review.

Authors:  Varut Lohsiriwat; Romyen Jitmungngan
Journal:  Medicina (Kaunas)       Date:  2022-03-12       Impact factor: 2.430

  3 in total

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