Roisin McMackin1, Stefan Dukic1,2, Emmet Costello1, Marta Pinto-Grau1,3, Antonio Fasano1, Teresa Buxo1, Mark Heverin1, Richard Reilly4,5, Muthuraman Muthuraman6, Niall Pender1,3, Orla Hardiman1,7, Bahman Nasseroleslami1. 1. Academic Unit of Neurology, Trinity College Dublin, The University of Dublin, Dublin, D02 R590, Ireland. 2. Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. 3. Beaumont Hospital Dublin, Department of Psychology, Dublin 9, Dublin, Ireland. 4. Trinity College Institute of Neuroscience, Trinity College Dublin, The University of Dublin, Dublin 2, Dublin, Ireland. 5. Trinity Centre for Biomedical Engineering, Trinity College, The University of Dublin, Dublin 2, Dublin, Ireland. 6. Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Johannes-Gutenberg- University Hospital, D55131, Mainz, Germany. 7. Department of Neurology, Beaumont Hospital Dublin, Dublin 9, Dublin, Ireland.
Abstract
OBJECTIVE: To identify cortical regions engaged during the sustained attention to response task (SART) and characterize changes in their activity associated with the neurodegenerative condition amyotrophic lateral sclerosis (ALS). METHODS: High-density electroencephalography (EEG) was recorded from 33 controls and 23 ALS patients during a SART paradigm. Differences in associated event-related potential peaks were measured for Go and NoGo trials. Sources active during these peaks were localized, and ALS-associated differences were quantified. RESULTS: Go and NoGo N2 and P3 peak sources were localized to the left primary motor cortex, bilateral dorsolateral prefrontal cortex (DLPFC), and lateral posterior parietal cortex (PPC). NoGo trials evoked greater bilateral medial PPC activity during N2 and lesser left insular, PPC and DLPFC activity during P3. Widespread cortical hyperactivity was identified in ALS during P3. Changes in the inferior parietal lobule and insular activity provided very good discrimination (AUROC > 0.75) between patients and controls. Activation of the right precuneus during P3 related to greater executive function in ALS, indicative of a compensatory role. INTERPRETATION: The SART engages numerous frontal and parietal cortical structures. SART-EEG measures correlate with specific cognitive impairments that can be localized to specific structures, aiding in differential diagnosis.
OBJECTIVE: To identify cortical regions engaged during the sustained attention to response task (SART) and characterize changes in their activity associated with the neurodegenerative condition amyotrophic lateral sclerosis (ALS). METHODS: High-density electroencephalography (EEG) was recorded from 33 controls and 23 ALS patients during a SART paradigm. Differences in associated event-related potential peaks were measured for Go and NoGo trials. Sources active during these peaks were localized, and ALS-associated differences were quantified. RESULTS: Go and NoGo N2 and P3 peak sources were localized to the left primary motor cortex, bilateral dorsolateral prefrontal cortex (DLPFC), and lateral posterior parietal cortex (PPC). NoGo trials evoked greater bilateral medial PPC activity during N2 and lesser left insular, PPC and DLPFC activity during P3. Widespread cortical hyperactivity was identified in ALS during P3. Changes in the inferior parietal lobule and insular activity provided very good discrimination (AUROC > 0.75) between patients and controls. Activation of the right precuneus during P3 related to greater executive function in ALS, indicative of a compensatory role. INTERPRETATION: The SART engages numerous frontal and parietal cortical structures. SART-EEG measures correlate with specific cognitive impairments that can be localized to specific structures, aiding in differential diagnosis.
Authors: Vladimir Fonov; Alan C Evans; Kelly Botteron; C Robert Almli; Robert C McKinstry; D Louis Collins Journal: Neuroimage Date: 2010-07-23 Impact factor: 6.556
Authors: E P Hart; E M Dumas; R H A M Reijntjes; K van der Hiele; S J A van den Bogaard; H A M Middelkoop; R A C Roos; J G van Dijk Journal: J Neurol Date: 2011-12-06 Impact factor: 4.849
Authors: Stefan Dukic; Roisin McMackin; Emmet Costello; Marjorie Metzger; Teresa Buxo; Antonio Fasano; Rangariroyashe Chipika; Marta Pinto-Grau; Christina Schuster; Michaela Hammond; Mark Heverin; Amina Coffey; Michael Broderick; Parameswaran M Iyer; Kieran Mohr; Brighid Gavin; Russell McLaughlin; Niall Pender; Peter Bede; Muthuraman Muthuraman; Leonard H van den Berg; Orla Hardiman; Bahman Nasseroleslami Journal: Brain Date: 2022-04-18 Impact factor: 15.255