Franco Scinicariello1, Melanie C Buser2, Henry G Abadin2, Roberta Attanasio3. 1. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, 30341, USA. Electronic address: fes6@cdc.gov. 2. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, 30341, USA. 3. Department of Biology, Georgia State University, Atlanta, GA, USA.
Abstract
BACKGROUND: Perfluoroalkyl acids (PFAAs) are man-made compounds that are persistent in the environment and highly bioaccumulative in the body. Humans are exposed to a mixture of these substances, and the effects of these mixtures may be different than the effects noted for individual compounds. Prenatal exposure to PFAAs has been associated with decreased birth weight. The objective of the present study is to evaluate concurrent serum PFAA levels, as single compounds and as mixtures, in relation to anthropomorphic measures in children. METHODS: Using multivariate linear regression, we evaluated the association between single or PFAA mixtures and with height-for-age (HAZ), weight-for-age (WAZ), and BMI (BMIZ) z-scores in children (ages 3-11 years) participants of the National Health and Nutrition Examination Survey (NHANES) 2013-2014. Analyses were also stratified by sex. The PFAA mixture was based on relative potency factors express in terms of PFOA equivalency (CmixRPFi) or as molar sum of the PFAA congeners (∑molPFAA). RESULTS: There was a statistically significant association of PFHxS and PFOS with decreased HAZ in boys. The significantly decreased HAZ in boys was also found when the PFAAs were analyzed as mixtures: CmixRPFi (β = -0.33; 95%CI: 0.63, -0.04) or ΣmolPFAAs (β = -0.30; 95%CI: 0.56, -0.04). In boys, PFHxS was also associated with decreased WAZ and BMIZ. The only statistically significant association found in girls was between decreased HAZ and PFHxS. CONCLUSIONS: We found sex differences in the association between concurrent serum PFAA levels and anthropomorphic measures in children 3-11 years old. PFAA levels, as single congeners or as mixture concentrations were associated with decreased height-for-age z-score in boys. Published by Elsevier Inc.
BACKGROUND:Perfluoroalkyl acids (PFAAs) are man-made compounds that are persistent in the environment and highly bioaccumulative in the body. Humans are exposed to a mixture of these substances, and the effects of these mixtures may be different than the effects noted for individual compounds. Prenatal exposure to PFAAs has been associated with decreased birth weight. The objective of the present study is to evaluate concurrent serum PFAA levels, as single compounds and as mixtures, in relation to anthropomorphic measures in children. METHODS: Using multivariate linear regression, we evaluated the association between single or PFAA mixtures and with height-for-age (HAZ), weight-for-age (WAZ), and BMI (BMIZ) z-scores in children (ages 3-11 years) participants of the National Health and Nutrition Examination Survey (NHANES) 2013-2014. Analyses were also stratified by sex. The PFAA mixture was based on relative potency factors express in terms of PFOA equivalency (CmixRPFi) or as molar sum of the PFAA congeners (∑molPFAA). RESULTS: There was a statistically significant association of PFHxS and PFOS with decreased HAZ in boys. The significantly decreased HAZ in boys was also found when the PFAAs were analyzed as mixtures: CmixRPFi (β = -0.33; 95%CI: 0.63, -0.04) or ΣmolPFAAs (β = -0.30; 95%CI: 0.56, -0.04). In boys, PFHxS was also associated with decreased WAZ and BMIZ. The only statistically significant association found in girls was between decreased HAZ and PFHxS. CONCLUSIONS: We found sex differences in the association between concurrent serum PFAA levels and anthropomorphic measures in children 3-11 years old. PFAA levels, as single congeners or as mixture concentrations were associated with decreased height-for-age z-score in boys. Published by Elsevier Inc.
Authors: Christopher Lau; Julie R Thibodeaux; Roger G Hanson; Michael G Narotsky; John M Rogers; Andrew B Lindstrom; Mark J Strynar Journal: Toxicol Sci Date: 2006-01-16 Impact factor: 4.849
Authors: Kaberi P Das; Brian E Grey; Mitchell B Rosen; Carmen R Wood; Katoria R Tatum-Gibbs; R Daniel Zehr; Mark J Strynar; Andrew B Lindstrom; Christopher Lau Journal: Reprod Toxicol Date: 2014-12-25 Impact factor: 3.143
Authors: Shu-Ching Chang; Julie R Thibodeaux; Mary L Eastvold; David J Ehresman; James A Bjork; John W Froehlich; Christopher Lau; Ravinder J Singh; Kendall B Wallace; John L Butenhoff Journal: Toxicology Date: 2007-10-26 Impact factor: 4.221
Authors: Yan Wang; Margaret Adgent; Pen-Hua Su; Hsiao-Yen Chen; Pau-Chung Chen; Chao A Hsiung; Shu-Li Wang Journal: Environ Health Perspect Date: 2016-02-19 Impact factor: 9.031
Authors: Paula I Johnson; Patrice Sutton; Dylan S Atchley; Erica Koustas; Juleen Lam; Saunak Sen; Karen A Robinson; Daniel A Axelrad; Tracey J Woodruff Journal: Environ Health Perspect Date: 2014-06-25 Impact factor: 9.031
Authors: Jerrold J Heindel; Sarah Howard; Keren Agay-Shay; Juan P Arrebola; Karine Audouze; Patrick J Babin; Robert Barouki; Amita Bansal; Etienne Blanc; Matthew C Cave; Saurabh Chatterjee; Nicolas Chevalier; Mahua Choudhury; David Collier; Lisa Connolly; Xavier Coumoul; Gabriella Garruti; Michael Gilbertson; Lori A Hoepner; Alison C Holloway; George Howell; Christopher D Kassotis; Mathew K Kay; Min Ji Kim; Dominique Lagadic-Gossmann; Sophie Langouet; Antoine Legrand; Zhuorui Li; Helene Le Mentec; Lars Lind; P Monica Lind; Robert H Lustig; Corinne Martin-Chouly; Vesna Munic Kos; Normand Podechard; Troy A Roepke; Robert M Sargis; Anne Starling; Craig R Tomlinson; Charbel Touma; Jan Vondracek; Frederick Vom Saal; Bruce Blumberg Journal: Biochem Pharmacol Date: 2022-04-05 Impact factor: 6.100
Authors: Mathilde Lolk Thomsen; Louise Scheutz Henriksen; Jeanette Tinggaard; Flemming Nielsen; Tina Kold Jensen; Katharina M Main Journal: Environ Health Date: 2021-06-28 Impact factor: 5.984
Authors: Cristina Canova; Andrea Di Nisio; Giulia Barbieri; Francesca Russo; Tony Fletcher; Erich Batzella; Teresa Dalla Zuanna; Gisella Pitter Journal: Int J Environ Res Public Health Date: 2021-12-07 Impact factor: 3.390
Authors: Yun Jeong Lee; Hae Woon Jung; Hwa Young Kim; Yoon-Jung Choi; Young Ah Lee Journal: Front Endocrinol (Lausanne) Date: 2021-09-09 Impact factor: 5.555