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Literature DB >> 32314693

Case Report: Cutaneous Leishmaniasis due to Leishmania (Viannia) panamensis in Two Travelers Successfully Treated with Miltefosine.

S Mann¹, T Phupitakphol¹, B Davis², S Newman³, J A Suarez⁴, A Henao-Martínez¹, C Franco-Paredes^1,5.

Abstract

We present two cases of Leishmania (V) panamensis in returning travelers from Central America successfully treated with miltefosine. The couple presented with ulcerative skin lesions nonresponsive to antibiotics. Skin biopsy with polymerase chain reaction (PCR) revealed L. (V) panamensis. To prevent the development of mucosal disease and avoid the inconvenience of parental therapy, we treated both patients with oral miltefosine. We suggest that miltefosine represents an important therapeutic alternative in the treatment of cutaneous lesions caused by L. panamensis and in preventing mucosal involvement.

Entities: Chemical

Mesh：

Substances：

Year: 2020 PMID： 32314693 PMCID： PMC7470566 DOI： 10.4269/ajtmh.20-0086

Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345

18 in total

1. An appraisal of the taxonomy and nomenclature of trypanosomatids presently classified as Leishmania and Endotrypanum.

Authors: O A Espinosa; M G Serrano; E P Camargo; M M G Teixeira; J J Shaw
Journal: Parasitology Date: 2016-12-15 Impact factor: 3.234

Review 2. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.

Authors: J D Berman
Journal: Clin Infect Dis Date: 1997-04 Impact factor: 9.079

3. Onset of espundia after many years of occult infection with Leishmania braziliensis.

Authors: B C Walton; L V Chinel; O Eguia y Eguia
Journal: Am J Trop Med Hyg Date: 1973-11 Impact factor: 2.345

4. Cutaneous leishmaniasis in the 21st century: from the laboratory to the bedside.

Authors: Sapha Barkati; Momar Ndao; Michael Libman
Journal: Curr Opin Infect Dis Date: 2019-10 Impact factor: 4.915

5. Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).

Authors: Naomi Aronson; Barbara L Herwaldt; Michael Libman; Richard Pearson; Rogelio Lopez-Velez; Peter Weina; Edgar M Carvalho; Moshe Ephros; Selma Jeronimo; Alan Magill
Journal: Clin Infect Dis Date: 2016-11-14 Impact factor: 9.079

6. Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.

Authors: María P Sánchez-Cañete; Luís Carvalho; F Javier Pérez-Victoria; Francisco Gamarro; Santiago Castanys
Journal: Antimicrob Agents Chemother Date: 2009-02-02 Impact factor: 5.191

7. Miltefosine for new world cutaneous leishmaniasis.

Authors: J Soto; B A Arana; J Toledo; N Rizzo; J C Vega; A Diaz; M Luz; P Gutierrez; M Arboleda; J D Berman; K Junge; J Engel; H Sindermann
Journal: Clin Infect Dis Date: 2004-04-09 Impact factor: 9.079

8. Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.

Authors: Paulo R Machado; Julia Ampuero; Luiz H Guimarães; Leonardo Villasboas; Ana T Rocha; Albert Schriefer; Rosana S Sousa; Anette Talhari; Gerson Penna; Edgar M Carvalho
Journal: PLoS Negl Trop Dis Date: 2010-12-21

9. Liposomal amphotericin B in travelers with cutaneous and muco-cutaneous leishmaniasis: Not a panacea.

Authors: Romain Guery; Benoit Henry; Guillaume Martin-Blondel; Claire Rouzaud; Florence Cordoliani; Gundel Harms; Jean-Pierre Gangneux; Françoise Foulet; Emmanuelle Bourrat; Michel Baccard; Gloria Morizot; Paul-Henri Consigny; Antoine Berry; Johannes Blum; Olivier Lortholary; Pierre Buffet
Journal: PLoS Negl Trop Dis Date: 2017-11-20

Case Report: Cutaneous Leishmaniasis due to Leishmania (Viannia) panamensis in Two Travelers Successfully Treated with Miltefosine.

1. An appraisal of the taxonomy and nomenclature of trypanosomatids presently classified as Leishmania and Endotrypanum.

Review 2. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.

3. Onset of espundia after many years of occult infection with Leishmania braziliensis.

4. Cutaneous leishmaniasis in the 21st century: from the laboratory to the bedside.

5. Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).

6. Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug.

7. Miltefosine for new world cutaneous leishmaniasis.

8. Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.

9. Liposomal amphotericin B in travelers with cutaneous and muco-cutaneous leishmaniasis: Not a panacea.

10. First Case of Diffuse Leishmaniasis Associated With Leishmania panamensis.

1. False-positive rapid diagnostic test for malaria in new world cutaneous leishmaniasis: a tale of two travelers.

Review 2. A Review of Leishmaniasis: Current Knowledge and Future Directions.

Review 3. Non-Endemic Leishmaniases Reported Globally in Humans between 2000 and 2021-A Comprehensive Review.

4. Complex cutaneous infection by Leishmania mexicana treated with miltefosine.