Literature DB >> 32314221

Method to Study Skin Cancer: Two-Stage Chemically Induced Carcinogenesis in Mouse Skin.

Andrei N Mardaryev1.   

Abstract

Two-stage chemical carcinogenesis method is widely used to elucidate genetic and molecular changes that lead to skin cancer development, as well as to test chemotherapeutic properties of novel drugs. This protocol allows researchers to reliably induce benign papilloma development and their conversion to squamous cell carcinoma in the skin of susceptible mouse strains in response to a single dose of carcinogen 2,4-dimethoxybenzaldehyde (DMBA) and repetitive applications of tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).

Entities:  

Keywords:  Chemical carcinogenesis; DMBA; Papilloma; Skin; Squamous cell carcinoma; TPA

Mesh：

Substances：

Year:  2020        PMID： 32314221     DOI： 10.1007/978-1-0716-0648-3_19

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

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Authors:  J C Zenklusen; L C Hodges; C J Conti
Journal:  Oncogene       Date:  1997-01-09       Impact factor: 9.867

Review 2.  Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.

Authors:  Ajit K Verma; Deric L Wheeler; Moammir H Aziz; Herbert Manoharan
Journal:  Mol Carcinog       Date:  2006-06       Impact factor: 4.784

3.  Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.

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Journal:  Oncogene       Date:  2000-06-15       Impact factor: 9.867

Review 4.  Modeling cutaneous squamous carcinoma development in the mouse.

Authors:  Phillips Y Huang; Allan Balmain
Journal:  Cold Spring Harb Perspect Med       Date:  2014-09-02       Impact factor: 6.915

5.  Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.

Authors:  Erika L Abel; Joe M Angel; Kaoru Kiguchi; John DiGiovanni
Journal:  Nat Protoc       Date:  2009-08-27       Impact factor: 13.491

Review 6.  Genetic factors controlling responsiveness to skin tumor promotion in mice.

Authors:  J DiGiovanni
Journal:  Prog Clin Biol Res       Date:  1995

Review 7.  Chemically induced skin carcinogenesis: Updates in experimental models (Review).

Authors:  Monica Neagu; Constantin Caruntu; Carolina Constantin; Daniel Boda; Sabina Zurac; Demetrios A Spandidos; Aristidis M Tsatsakis
Journal:  Oncol Rep       Date:  2016-03-17       Impact factor: 3.906

8.  Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.

Authors:  Gerline C van de Glind; Jacoba J Out-Luiting; Heggert G Rebel; Cornelis P Tensen; Frank R de Gruijl
Journal:  Oncotarget       Date:  2016-08-09

9.  Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.

Authors:  Gerline C van de Glind; Heggert G Rebel; Jacoba J Out-Luiting; Wim Zoutman; Cornelis P Tensen; Frank R de Gruijl
Journal:  Oncotarget       Date:  2016-12-27

10.  Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner.

Authors:  Zijie Su; Jiaxing Song; Zhongyuan Wang; Liang Zhou; Yuqing Xia; Shubin Yu; Qi Sun; Shan-Shan Liu; Liang Zhao; Shiyue Li; Lei Wei; Dennis A Carson; Desheng Lu
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-23       Impact factor: 11.205
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