Xiaoling Duan1, Man Zhao1, Shenglei Zhang2, Zhibin Xu3, Lili Mi1, Jianfei Shi1, Xiaoying Ma4, Yueping Liu5, Ning Li1, Xiaolei Yin1, Xin Han1, Guangjie Han1, Jinfeng Wang1, Jinsheng Xu6, Fei Yin7. 1. Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050019, Hebei, People's Republic of China. 2. Department of Nephrology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050019, Hebei, People's Republic of China. 3. Department of Endoscope Room, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050019, Hebei, China. 4. Department of Nephrology, Cangzhou Central Hospital, Xinhua Road, Cangzhou, 061000, Hebei, China. 5. Department of Pathology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050019, Hebei, China. 6. Department of Nephrology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050019, Hebei, People's Republic of China. xjs5766@126.com. 7. Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050019, Hebei, People's Republic of China. yinfei_4y@sina.com.
Abstract
OBJECTIVE: To explore whether the distance of rectal neuroendocrine neoplasms from the anal margin has an impact on the prognosis of patients and evaluate lymphatic metastases risk score for colorectal neuroendocrine neoplasms (NENs). METHODS: Clinical pathological and follow-up data of 71 patients identified as colorectal neuroendocrine neoplasms by pathology from July 2011 to July 2019 were carefully collected. RESULTS: Among 71 patients with colorectal NENs, most of the tumors were rectal NENs (62 cases). A total of 26 patients were in the presence of lymph node metastasis, and 44 patients had negative lymph nodes. Patients with lesions from the anal margin > 5 cm in rectum have a better prognosis (P = 0.022). Tumor stage (P = 0.034) and grade (P = 0.001) were independent risk predictors of lymphatic metastases. We developed a lymphatic metastasis risk score for rectal NENs, and patients with the score ≥ 7.5 were more likely to develop lymph node metastases (area 0.958, 95% CI 0.903-1.000, P = 0.000) with a sensitivity of 72.2% and a specificity of 97.3%. CONCLUSION: Patients with lesions from the anal margin > 5 cm and lymphatic metastasis risk score ≥ 7.5 should be treated actively.
OBJECTIVE: To explore whether the distance of rectal neuroendocrine neoplasms from the anal margin has an impact on the prognosis of patients and evaluate lymphatic metastases risk score for colorectal neuroendocrine neoplasms (NENs). METHODS: Clinical pathological and follow-up data of 71 patients identified as colorectal neuroendocrine neoplasms by pathology from July 2011 to July 2019 were carefully collected. RESULTS: Among 71 patients with colorectal NENs, most of the tumors were rectal NENs (62 cases). A total of 26 patients were in the presence of lymph node metastasis, and 44 patients had negative lymph nodes. Patients with lesions from the anal margin > 5 cm in rectum have a better prognosis (P = 0.022). Tumor stage (P = 0.034) and grade (P = 0.001) were independent risk predictors of lymphatic metastases. We developed a lymphatic metastasis risk score for rectal NENs, and patients with the score ≥ 7.5 were more likely to develop lymph node metastases (area 0.958, 95% CI 0.903-1.000, P = 0.000) with a sensitivity of 72.2% and a specificity of 97.3%. CONCLUSION:Patients with lesions from the anal margin > 5 cm and lymphatic metastasis risk score ≥ 7.5 should be treated actively.
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