Spontaneous splenic rupture associated with Escherichia coli bacteremia and dual antiplatelet therapy.

Splenic rupture is a life-threatening condition that usually occurs after blunt abdominal trauma. It can lead to hemorrhagic shock and death if not diagnosed quickly. Rarely, spontaneous rupture of the spleen may occur without a history of trauma. In these cases, establishing a diagnosis is challenging due to the ambiguous presentation of the conditions associated with it. Infections and hematological malignancies are the two most common causes of spontaneous splenic rupture. Here, we report a case of spontaneous splenic rupture in the setting of Gram-negative bacteremia and recent initiation of dual antiplatelet therapy.