Young Chul Youn1, Byoung Sub Lee2, Gwang Je Kim2, Ji Sun Ryu2, Kuntaek Lim2, Ryan Lee2, Jeewon Suh3, Young Ho Park3, Jung-Min Pyun3, Nayoung Ryu3, Min Ju Kang4, Hye Ryoun Kim5, Sungmin Kang2, Seong Soo A An6, SangYun Kim3. 1. Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea. 2. Research and Development, PeopleBio Inc., Gyeonggi-do, Republic of Korea. 3. Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea. 4. Department of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea. 5. Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea. 6. Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea.
Abstract
BACKGROUND: Oligomeric amyloid-β (Aβ) is one of the major contributors to the pathomechanism of Alzheimer's disease (AD); Aβ oligomerization in plasma can be measured using a Multimer Detection System-Oligomeric Aβ (MDS-OAβ) after incubation with spiked synthetic Aβ. OBJECTIVE: We evaluated the clinical sensitivity and specificity of the MDS-OAβ values for prediction of AD. METHODS: The MDS-OAβ values measured using inBlood™ OAβ test in heparin-treated plasma samples from 52 AD patients in comparison with 52 community-based subjects with normal cognition (NC). The inclusion criterion was proposed by the NINCDS-ADRDA and additionally required at least 6 months of follow-up from the initial clinical diagnosis in the course of AD. RESULTS: The MDS-OAβ values were 1.43±0.30 ng/ml in AD and 0.45±0.19 (p < 0.001) in NC, respectively. Using a cut-off value of 0.78 ng/ml, the results revealed 100% sensitivity and 92.31% specificity. CONCLUSION: MDS-OAβ to measure plasma Aβ oligomerization is a valuable blood-based biomarker for clinical diagnosis of AD, with high sensitivity and specificity.
BACKGROUND: Oligomeric amyloid-β (Aβ) is one of the major contributors to the pathomechanism of Alzheimer's disease (AD); Aβ oligomerization in plasma can be measured using a Multimer Detection System-Oligomeric Aβ (MDS-OAβ) after incubation with spiked synthetic Aβ. OBJECTIVE: We evaluated the clinical sensitivity and specificity of the MDS-OAβ values for prediction of AD. METHODS: The MDS-OAβ values measured using inBlood™ OAβ test in heparin-treated plasma samples from 52 ADpatients in comparison with 52 community-based subjects with normal cognition (NC). The inclusion criterion was proposed by the NINCDS-ADRDA and additionally required at least 6 months of follow-up from the initial clinical diagnosis in the course of AD. RESULTS: The MDS-OAβ values were 1.43±0.30 ng/ml in AD and 0.45±0.19 (p < 0.001) in NC, respectively. Using a cut-off value of 0.78 ng/ml, the results revealed 100% sensitivity and 92.31% specificity. CONCLUSION: MDS-OAβ to measure plasma Aβ oligomerization is a valuable blood-based biomarker for clinical diagnosis of AD, with high sensitivity and specificity.
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