Gaurav Aggarwal1, Giuseppe Lippi2, Brandon Michael Henry3. 1. Department of Medicine, Jersey City Medical Center, Jersey City, USA. 2. Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy. 3. Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Abstract
INTRODUCTION: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown. METHOD: We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19. RESULTS: A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection. DISCUSSION: Our findings are limited by a small number of studies and sample size. CONCLUSION: There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.
INTRODUCTION: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown. METHOD: We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19. RESULTS: A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19infection. DISCUSSION: Our findings are limited by a small number of studies and sample size. CONCLUSION: There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.
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