Guadalupe Marco-Martín1, Pilar Tornero1, Alicia Prieto1, Alejandro La Rotta1, Teresa Herrero1, Maria Luisa Baeza1. 1. Allergy Department Hospital General Universitario Gregorio Marañón (GM-M, PT, AP, ALR, TH, MLB); Allergy Department (GM-M), Hospital Universitario Infanta Sofía, Madrid; Allergy Department (ALR), Policlínica Miramar, Palma de Mallorca; Biomedical Research Network on Rare Diseases (U761 CIBERER) (MLB), Instituto de Salud Carlos III; and Institute for Health Research Gregorio Marañón (IIS-GM) (MLB), Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Abstract
PURPOSE OF REVIEW: Diverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may lead to discontinuation of GA. RECENT FINDINGS: Close collaboration between the allergy and neurology departments is needed to study adverse reactions to GA. The allergy study should include a detailed history and skin prick and intradermal tests with GA and, if possible, determination of specific IgE levels. Furthermore, the implication of other drugs should be ruled out. SUMMARY: An accurate diagnosis of reactions to GA is essential if we are to confirm or rule out allergy to GA. When an allergy diagnosis is confirmed or firmly suspected based on clinical evidence, desensitization protocols are increasingly seen as safe methods for reintroduction of GA.
PURPOSE OF REVIEW: Diverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may lead to discontinuation of GA. RECENT FINDINGS: Close collaboration between the allergy and neurology departments is needed to study adverse reactions to GA. The allergy study should include a detailed history and skin prick and intradermal tests with GA and, if possible, determination of specific IgE levels. Furthermore, the implication of other drugs should be ruled out. SUMMARY: An accurate diagnosis of reactions to GA is essential if we are to confirm or rule out allergy to GA. When an allergy diagnosis is confirmed or firmly suspected based on clinical evidence, desensitization protocols are increasingly seen as safe methods for reintroduction of GA.
Authors: J Sánchez-López; P Rodríguez del Rio; B Cases-Ortega; C Martínez-Cócera; M Fernández-Rivas Journal: J Investig Allergol Clin Immunol Date: 2010 Impact factor: 4.333