Xu X, Yu H, Xu Y. Cancer Manag Res. 2019;11:9153–9163.The Editor-in-Chief and Publisher of Cancer Management and Research wish to issue an Expression of Concern for the published article.After publication of article, Ras-ERK1/2 Signaling Promotes The Development Of Osteosarcoma By Regulating H2BK12ac Through CBP; Xu X, Yu H, Xu Y. Cancer Management and Research 2019;11:9153–9163, questions about the scientific integrity of the article content were brought to the Publisher and Editor’s attention. We have reached out to the authors requesting that they supply information that would confirm the article’s integrity, but the authors have not responded to our queries within the requested timeframe. Therefore, as we continue to work through the issues raised, we advise readers to interpret the information presented in the article with due caution.