| Literature DB >> 32307696 |
Aarthi Rajesh1, Gabriella Stuart2, Nicola Real2, Jenny Ahn3, Allison Tschirley1, Lyn Wise2, Merilyn Hibma1.
Abstract
Langerin is a C-type lectin receptor that is expressed on Langerhans cells and langerin-positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full-thickness excision wound were investigated using the langerin-DTR depletable mouse. Strikingly, depletion of langerin+ cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin+ -cell-depleted group was characterized by enhanced neo-epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin+ cells was associated with increased levels of granulocyte-macrophage colony-stimulating factor, F4/80+ cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin+ cells during wound healing. Therapies that suppress langerin+ cells or their function may therefore have utility in progressing the healing of wounds in humans.Entities:
Keywords: Langerhans cells; angiogenesis; epithelialization; langerin-positive dermal dendritic cells; mouse; skin; wound healing
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Year: 2020 PMID： 32307696 PMCID： PMC7370135 DOI： 10.1111/imm.13202
Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397