Neena A Davisson1, Zachary L Bercu1, Sarah C Friend2, Elisavet Paplomata2, Robert M Ermentrout1, Janice Newsome1, Bill S Majdalany1, Nima Kokabi3. 1. Division of Interventional Radiology, Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd. NE, Suite D112, Atlanta, GA 30322. 2. Division of Medical Oncology, Department of Medicine, Emory University School of Medicine, 1364 Clifton Rd. NE, Suite D112, Atlanta, GA 30322. 3. Division of Interventional Radiology, Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd. NE, Suite D112, Atlanta, GA 30322. Electronic address: nkokabi@emory.edu.
Abstract
PURPOSE: To determine predictors of survival after transarterial radioembolization of hepatic metastases from breast cancer. MATERIALS AND METHODS: Twenty-four patients with chemotherapy-refractory hepatic metastases from breast cancer who underwent radioembolization from 2013 to 2018 were evaluated based on various demographic and clinical factors before and after treatment. Overall survival (OS) was estimated by Kaplan-Meier method. Log-rank analysis was performed to determine predictors of prolonged OS from the time of first radioembolization and first hepatic metastasis diagnosis. RESULTS: Median OS times were 35.4 and 48.6 months from first radioembolization and time of hepatic metastasis diagnosis, respectively. Radioembolization within 6 months of hepatic metastasis diagnosis was a positive predictor of survival from first radioembolization, with median OS of 38.9 months vs 22.1 months for others (P = .033). Estrogen receptor (ER)-positive status predicted prolonged survival (38.6 months for ER+ vs 5.4 months for ER-; P = .005). The presence of abdominal pain predicted poor median OS: 12.8 months vs 38.6 months for others (P < .001). The presence of ascites was also a negative predictor of OS (1.7 months vs 35.4 months for others; P = .037), as was treatment-related grade ≥ 2 toxicity at 3 months (5.4 months vs 38.6 months for others; P = .017). CONCLUSIONS: In patients with metastatic breast cancer, radioembolization within 6 months of hepatic metastasis diagnosis and ER+ status appear to be positive predictors of prolonged survival. Conversely, baseline abdominal pain, baseline ascites, and treatment-related grade ≥ 2 toxicity at 3 months after treatment appear to be negative predictors of OS.
PURPOSE: To determine predictors of survival after transarterial radioembolization of hepatic metastases from breast cancer. MATERIALS AND METHODS: Twenty-four patients with chemotherapy-refractory hepatic metastases from breast cancer who underwent radioembolization from 2013 to 2018 were evaluated based on various demographic and clinical factors before and after treatment. Overall survival (OS) was estimated by Kaplan-Meier method. Log-rank analysis was performed to determine predictors of prolonged OS from the time of first radioembolization and first hepatic metastasis diagnosis. RESULTS: Median OS times were 35.4 and 48.6 months from first radioembolization and time of hepatic metastasis diagnosis, respectively. Radioembolization within 6 months of hepatic metastasis diagnosis was a positive predictor of survival from first radioembolization, with median OS of 38.9 months vs 22.1 months for others (P = .033). Estrogen receptor (ER)-positive status predicted prolonged survival (38.6 months for ER+ vs 5.4 months for ER-; P = .005). The presence of abdominal pain predicted poor median OS: 12.8 months vs 38.6 months for others (P < .001). The presence of ascites was also a negative predictor of OS (1.7 months vs 35.4 months for others; P = .037), as was treatment-related grade ≥ 2 toxicity at 3 months (5.4 months vs 38.6 months for others; P = .017). CONCLUSIONS: In patients with metastatic breast cancer, radioembolization within 6 months of hepatic metastasis diagnosis and ER+ status appear to be positive predictors of prolonged survival. Conversely, baseline abdominal pain, baseline ascites, and treatment-related grade ≥ 2 toxicity at 3 months after treatment appear to be negative predictors of OS.
Authors: Cassidy R Dodson; Colin Marshall; Jared C Durieux; Patrick F Wojtylak; Jon C Davidson; Raymond F Muzic; Arash Kardan Journal: Cardiovasc Intervent Radiol Date: 2022-08-04 Impact factor: 2.797
Authors: Richard Wu; Keerthi Gogineni; Jane Meisel; Stephen Szabo; Meenakshi Thirunavu; Sarah Friend; Zachary Bercu; Ila Sethi; Neela Natarajan; Jeffrey Switchenko; Jason Levy; Eddie Abdalla; Laura Weakland; Kevin Kalinsky; Nima Kokabi Journal: Cardiovasc Intervent Radiol Date: 2022-08-25 Impact factor: 2.797
Authors: B M Aarts; F M Gómez Muñoz; H Wildiers; V O Dezentjé; T R Baetens; W Schats; M Lopez-Yurda; R C Dresen; B J de Wit-van der Veen; C M Deroose; G Maleux; R G H Beets-Tan; E G Klompenhouwer Journal: Cardiovasc Intervent Radiol Date: 2021-07-28 Impact factor: 2.740
Authors: Elie Barakat; Andras Bibok; Anupam Rishi; Altan Ahmed; Jessica M Frakes; Sarah E Hoffe; Avan J Armaghani; Aixa E Soyano; Ricardo L B Costa; Ghassan El-Haddad; Junsung Choi; Bela Kis Journal: Adv Radiat Oncol Date: 2021-10-29