| Literature DB >> 32304992 |
Abdullah Al Mamun1, Yanqing Wu2, Chang Jia3, Fahad Munir4, Kasfia Jahan Sathy5, Tamanna Sarker6, Ilma Monalisa6, Kailiang Zhou7, Jian Xiao8.
Abstract
Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future.Entities:
Keywords: Caspase-1, liver diseases; NLRP3; Non-alcoholic fatty liver disease; Pyroptosis
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Year: 2020 PMID： 32304992 DOI： 10.1016/j.intimp.2020.106489
Source DB: PubMed Journal: Int Immunopharmacol ISSN： 1567-5769 Impact factor: 4.932