Andrea L Barker1, Rachel L Eddy1, Jonathan L MacNeil2, David G McCormack3, Miranda Kirby4, Grace Parraga5. 1. Department of Medical Biophysics, Western University, London, Canada; Robarts Research Institute, Western University, 1151 Richmond St. N., London, Ontario N6A 5B7, Canada. 2. Robarts Research Institute, Western University, 1151 Richmond St. N., London, Ontario N6A 5B7, Canada; School of Biomedical Engineering, Western University, London, Canada. 3. Division of Respirology, Department of Medicine, Western University, London, Canada. 4. Department of Physics, Ryerson University, Toronto, Canada. 5. Department of Medical Biophysics, Western University, London, Canada; Robarts Research Institute, Western University, 1151 Richmond St. N., London, Ontario N6A 5B7, Canada; School of Biomedical Engineering, Western University, London, Canada; Division of Respirology, Department of Medicine, Western University, London, Canada. Electronic address: gparraga@robarts.ca.
Abstract
RATIONALE AND OBJECTIVES: The relationships between computed tomography (CT) pulmonary vascularity and MRI ventilation is not well-understood in chronic obstructive pulmonary disease (COPD) patients. Our objective was to evaluate CT pulmonary vascular and MRI ventilation measurements in ex-smokers and to investigate their associations and how such measurements change over time. MATERIALS AND METHODS: Ninety ex-smokers (n = 41 without COPD 71 ± 10 years and n = 49 COPD 71 ± 8 years) provided written informed-consent to an ethics-board approved protocol and underwent imaging and pulmonary-function-tests twice, 31 ± 7 months apart. 3He MRI was acquired to generate ventilation-defect-percent (VDP). CT measurements of the relative area-of-the-lung with attenuation <-950 Hounsfield units (RA950), pulmonary vascular total-blood-volume (TBV) and percent of vessels with radius < one voxel (PV1) were evaluated. RESULTS: At baseline, there were significant differences in RA950 (p = 0.0001), VDP (p = 0.0001), total-blood-volume (p = 0.0001) and PV1 (p = 0.01) between ex-smokers and COPD participants as well as for VDP (p = 0.0001) in COPD participants with and without emphysema. The annual FEV1 change (-40 ± 93 mL/year) was not different among participant subgroups (p = 0.87), but the annual RA950 (p = 0.01) and PV1 (p = 0.007) changes were significantly different in participants with an accelerated annual FEV1 decline as compared to participants with a diminished annual FEV1 decline. There were significant but weak relationships for PV1 with FEV1%pred (p = 0.02), FEV1/FVC (p = 0.001), and log RA950 (p = 0.0001), but not VDP (p=0.20). The mean change in PV1 was also weakly but significantly related to the change in RA950 (p = 0.02). CONCLUSION: CT pulmonary vascular measurements were significantly different in ex-smokers and participants with COPD and related to RA950 but not VDP worsening over 2.5 years.
RATIONALE AND OBJECTIVES: The relationships between computed tomography (CT) pulmonary vascularity and MRI ventilation is not well-understood in chronic obstructive pulmonary disease (COPD) patients. Our objective was to evaluate CT pulmonary vascular and MRI ventilation measurements in ex-smokers and to investigate their associations and how such measurements change over time. MATERIALS AND METHODS: Ninety ex-smokers (n = 41 without COPD 71 ± 10 years and n = 49 COPD 71 ± 8 years) provided written informed-consent to an ethics-board approved protocol and underwent imaging and pulmonary-function-tests twice, 31 ± 7 months apart. 3He MRI was acquired to generate ventilation-defect-percent (VDP). CT measurements of the relative area-of-the-lung with attenuation <-950 Hounsfield units (RA950), pulmonary vascular total-blood-volume (TBV) and percent of vessels with radius < one voxel (PV1) were evaluated. RESULTS: At baseline, there were significant differences in RA950 (p = 0.0001), VDP (p = 0.0001), total-blood-volume (p = 0.0001) and PV1 (p = 0.01) between ex-smokers and COPDparticipants as well as for VDP (p = 0.0001) in COPDparticipants with and without emphysema. The annual FEV1 change (-40 ± 93 mL/year) was not different among participant subgroups (p = 0.87), but the annual RA950 (p = 0.01) and PV1 (p = 0.007) changes were significantly different in participants with an accelerated annual FEV1 decline as compared to participants with a diminished annual FEV1 decline. There were significant but weak relationships for PV1 with FEV1%pred (p = 0.02), FEV1/FVC (p = 0.001), and log RA950 (p = 0.0001), but not VDP (p=0.20). The mean change in PV1 was also weakly but significantly related to the change in RA950 (p = 0.02). CONCLUSION: CT pulmonary vascular measurements were significantly different in ex-smokers and participants with COPD and related to RA950 but not VDP worsening over 2.5 years.
Authors: Dheyaa Alkhanfar; Yousef Shahin; Faisal Alandejani; Krit Dwivedi; Samer Alabed; Chris Johns; Allan Lawrie; A A Roger Thompson; Alexander M K Rothman; Juerg Tschirren; Johanna M Uthoff; Eric Hoffman; Robin Condliffe; Jim M Wild; David G Kiely; Andrew J Swift Journal: ERJ Open Res Date: 2022-05-16
Authors: Naz P Taskiran; Grant T Hiura; Xuzhe Zhang; R Graham Barr; Stephen M Dashnaw; Eric A Hoffman; Daniel Malinsky; Elizabeth C Oelsner; Martin R Prince; Benjamin M Smith; Yanping Sun; Yifei Sun; Jim M Wild; Wei Shen; Emlyn W Hughes Journal: Tomography Date: 2022-09-13