Literature DB >> 32303276

Wnt/β-Catenin in Acute Kidney Injury and Progression to Chronic Kidney Disease.

Tessa Huffstater1, W David Merryman1, Leslie S Gewin2.   

Abstract

Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI or prevent its progression to CKD. Wnt/β-catenin is a critical regulator of kidney development that is up-regulated after injury. Most of the literature support a beneficial role for Wnt/β-catenin in AKI, but suggest that this pathway promotes the progression of tubulointerstitial fibrosis, the hallmark of CKD progression. We review the role of Wnt/β-catenin in renal injury with a focus on its potential as a therapeutic target in AKI and in AKI to CKD transition.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Acute kidney injury; chronic kidney disease; β-catenin

Mesh：

Year:  2020        PMID： 32303276      PMCID： PMC7172007          DOI： 10.1016/j.semnephrol.2020.01.004

Source DB:  PubMed          Journal:  Semin Nephrol        ISSN： 0270-9295            Impact factor:   5.299


  87 in total

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Authors:  Joseph V Bonventre
Journal:  Kidney Int Suppl (2011)       Date:  2014-11
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Authors:  Siu Chiu Chan; Sachin S Hajarnis; Sophia M Vrba; Vishal Patel; Peter Igarashi
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5.  NK4 Regulates Laryngeal Squamous Cell Carcinoma Cell Properties and Inhibits Tumorigenicity by Modulating the DKK1/Wnt/β-Catenin Axis.

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6.  Expanded renal lymphatics improve recovery following kidney injury.

Authors:  Gaurav Baranwal; Heidi A Creed; Laurence M Black; Alexa Auger; Alexander M Quach; Rahul Vegiraju; Han E Eckenrode; Anupam Agarwal; Joseph M Rutkowski
Journal:  Physiol Rep       Date:  2021-11

7.  miR-25-3p protects renal tubular epithelial cells from apoptosis induced by renal IRI by targeting DKK3.

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10.  Editorial: Hypertension and Chronic Kidney Injury or Failure, Volume II.

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