Paola Caruso1, Miriam Longo2, Maurizio Gicchino3, Lorenzo Scappaticcio4, Mariangela Caputo5, Maria Ida Maiorino6, Giuseppe Bellastella7, Katherine Esposito8. 1. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy; Unit of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: paola.caruso@unicampania.it. 2. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy; Unit of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: miriam.longo@unicampania.it. 3. Unit of Diabetes, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: maurizio.gicchino@libero.it. 4. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy; Unit of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: lorenzo.scappaticcio@unicampania.it. 5. Unit of Diabetes, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: mariangela.caputo@unicampania.it. 6. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy; Unit of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: mariaida.maiorino@unicampania.it. 7. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy; Unit of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: giuseppe.bellastella@unicampania.it. 8. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy; Unit of Diabetes, University of Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy. Electronic address: katherine.esposito@unicampania.it.
Abstract
AIM: The aim of this study was to investigate the factors involved in healing failure in a population of patients with diabetic foot ulcers (DFU) after one year of follow-up. METHODS: One hundred and forty-four patients were treated for DFU in a tertiary-care center and had a regular follow-up for one year. Laboratory measurements and clinical assessments, including long-term diabetes complications and risk factors for DFU, were collected at baseline and patients were divided in two groups according to the outcome [Healed group (H, n = 91), and Not Healed group (NH, n = 53)]. RESULTS: Compared with H group, NH group had significant higher levels of urinary albumin excretion [H vs NH, median (IQR), 23.5 (10.1, 41.1) vs 26.4 (20.8, 141.1), P = 0.032] and significantly increased prevalence of diabetic kidney disease (DKD) (22% vs 40%, P = 0.038) and Charcot Arthropathy (3% vs 16%, P = 0.025). No differences among the other long-term complications of diabetes, risk factors for DFU or clinical features were found. The multiple logistic regression analysis identified DKD and Charcot Arthropathy as negative predictors of healing. CONCLUSIONS: In a population of people with type 2 diabetes with DFU treated in a tertiary-care center, DKD and Charcot Arthropathy were related to poor healing within one year-follow-up.
AIM: The aim of this study was to investigate the factors involved in healing failure in a population of patients with diabetic foot ulcers (DFU) after one year of follow-up. METHODS: One hundred and forty-four patients were treated for DFU in a tertiary-care center and had a regular follow-up for one year. Laboratory measurements and clinical assessments, including long-term diabetes complications and risk factors for DFU, were collected at baseline and patients were divided in two groups according to the outcome [Healed group (H, n = 91), and Not Healed group (NH, n = 53)]. RESULTS: Compared with H group, NH group had significant higher levels of urinary albumin excretion [H vs NH, median (IQR), 23.5 (10.1, 41.1) vs 26.4 (20.8, 141.1), P = 0.032] and significantly increased prevalence of diabetic kidney disease (DKD) (22% vs 40%, P = 0.038) and Charcot Arthropathy (3% vs 16%, P = 0.025). No differences among the other long-term complications of diabetes, risk factors for DFU or clinical features were found. The multiple logistic regression analysis identified DKD and Charcot Arthropathy as negative predictors of healing. CONCLUSIONS: In a population of people with type 2 diabetes with DFU treated in a tertiary-care center, DKD and Charcot Arthropathy were related to poor healing within one year-follow-up.