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Literature DB >> 32302592

The role of Drp1 in mitophagy and cell death in the heart.

Mingming Tong¹, Daniela Zablocki¹, Junichi Sadoshima².

Abstract

Maintenance of mitochondrial function and integrity is critical for normal cell survival, particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well-coordinated quality control mechanisms in cardiomyocytes, involving mitochondrial biogenesis, mitochondrial dynamics-fission and fusion, and mitophagy, act to protect against mitochondrial dysfunction. Mitochondrial fission, which requires dynamin-related protein 1 (Drp1), is essential for segregation of damaged mitochondria for degradation. Alterations in this process have been linked to cardiomyocyte apoptosis and cardiomyopathy. In this review, we discuss the role of Drp1 in mitophagy and apoptosis in the context of cardiac pathology, including myocardial ischemia and heart failure.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Apoptosis; Drp1; Heart; Mitochondrial fission; Mitophagy

Mesh：

Substances：

Year: 2020 PMID： 32302592 PMCID： PMC7545744 DOI： 10.1016/j.yjmcc.2020.04.015

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

94 in total

1. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes.

Authors: Bong Sook Jhun; Jin O-Uchi; Stephanie M Adaniya; Thomas J Mancini; Jessica L Cao; Michelle E King; Amy K Landi; Hanley Ma; Milla Shin; Donqin Yang; Xiaole Xu; Yisang Yoon; Gaurav Choudhary; Richard T Clements; Ulrike Mende; Shey-Shing Sheu
Journal: J Physiol Date: 2018-01-25 Impact factor: 5.182

2. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

Authors: Ann Cassidy-Stone; Jerry E Chipuk; Elena Ingerman; Cheng Song; Choong Yoo; Tomomi Kuwana; Mark J Kurth; Jared T Shaw; Jenny E Hinshaw; Douglas R Green; Jodi Nunnari
Journal: Dev Cell Date: 2008-02 Impact factor: 12.270

Review 3. Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart.

Authors: Wang Wang; Celia Fernandez-Sanz; Shey-Shing Sheu
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2017-09-14 Impact factor: 5.187

4. Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.

Authors: Yusuke Kageyama; Masahiko Hoshijima; Kinya Seo; Djahida Bedja; Polina Sysa-Shah; Shaida A Andrabi; Weiran Chen; Ahmet Höke; Valina L Dawson; Ted M Dawson; Kathleen Gabrielson; David A Kass; Miho Iijima; Hiromi Sesaki
Journal: EMBO J Date: 2014-10-27 Impact factor: 11.598

5. Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.

Authors: A U Joshi; A E Ebert; B Haileselassie; D Mochly-Rosen
Journal: J Mol Cell Cardiol Date: 2018-12-11 Impact factor: 5.000

6. Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes.

Authors: Abhinav Dhingra; Rahul Jayas; Pegah Afshar; Matthew Guberman; Graham Maddaford; Johnathan Gerstein; Brooke Lieberman; Hilary Nepon; Victoria Margulets; Rimpy Dhingra; Lorrie A Kirshenbaum
Journal: Free Radic Biol Med Date: 2017-08-30 Impact factor: 7.376

7. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury.

Authors: Sang-Bing Ong; Sapna Subrayan; Shiang Y Lim; Derek M Yellon; Sean M Davidson; Derek J Hausenloy
Journal: Circulation Date: 2010-04-26 Impact factor: 29.690

Review 8. Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.

Authors: Yoshiyuki Ikeda; Akihiro Shirakabe; Christopher Brady; Daniela Zablocki; Mitsuru Ohishi; Junichi Sadoshima
Journal: J Mol Cell Cardiol Date: 2014-10-07 Impact factor: 5.000

9. Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.

Authors: Marie-Hélène Disatnik; Julio C B Ferreira; Juliane Cruz Campos; Kátia Sampaio Gomes; Paulo M M Dourado; Xin Qi; Daria Mochly-Rosen
Journal: J Am Heart Assoc Date: 2013-10-08 Impact factor: 5.501

10. Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.

Authors: Wei-Ke Ji; Rajarshi Chakrabarti; Xintao Fan; Lori Schoenfeld; Stefan Strack; Henry N Higgs
Journal: J Cell Biol Date: 2017-11-20 Impact factor: 10.539

19 in total

Review 1. Pharmacological Anti-Remodelling Effects of Disease-Modifying Drugs in Heart Failure with Reduced Ejection Fraction.

Authors: Michele Correale; Pietro Mazzeo; Lucia Tricarico; Francesca Croella; Martino Fortunato; Michele Magnesa; Marco Amatruda; Simona Alfieri; Salvatore Ferrara; Vincenzo Ceci; Giuseppe Dattilo; Marco Mele; Massimo Iacoviello; Natale Daniele Brunetti
Journal: Clin Drug Investig Date: 2022-06-20 Impact factor: 2.859

2. A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics.

Authors: Xin Peng; Cong Zhang; Zhi-Min Zhou; Kun Wang; Jia-Wei Gao; Zhan-Yang Qian; Jun-Ping Bao; Hang-Yu Ji; V L F Cabral; Xiao-Tao Wu
Journal: Inflamm Res Date: 2022-04-15 Impact factor: 4.575

Review 3. Neurohormonal connections with mitochondria in cardiomyopathy and other diseases.

Authors: Gerald W Dorn
Journal: Am J Physiol Cell Physiol Date: 2022-06-27 Impact factor: 5.282

4. Bisphenol-A Mediated Impaired DRP1-GFER Axis and Cognition Restored by PGC-1α Upregulation Through Nicotinamide in the Rat Brain Hippocampus.

Authors: Shweta Goyal; Saurabh Tiwari; Brashket Seth; Ankit Tandon; Rajnish Kumar Chaturvedi
Journal: Mol Neurobiol Date: 2022-05-25 Impact factor: 5.682