Literature DB >> 32301180

The role of transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas.

Alexander A Strait1, Xiao-Jing Wang1,2.   

Abstract

Despite a decline in the incidence of squamous cell carcinomas (SCCs) over the past 20 years, their survival rate has remained nearly the same, indicating that treatment options have not improved relative to other cancer types. Immunotherapies have a high potential for a sustained effect in SCC patients, but their response rate is low. Here, we review the suppressive role of transforming growth factor-beta (TGFβ) on the antitumor immune response in SCC and present its potential as a therapeutic target in combination with the current range of immunotherapies available for SCC patients. We conclude that SCCs are an optimal cancer type to study the effectiveness of TGFβ inhibition due to the prevalence of dysregulated TGFβ signaling in them.
© 2020 Wiley Periodicals LLC.

Entities:  

Keywords:  head and neck squamous cell carcinoma; immune checkpoint blockade; immunotherapy; tumor microenvironment

Mesh：

Substances：

Year:  2020        PMID： 32301180      PMCID： PMC7282943          DOI： 10.1002/mc.23196

Source DB:  PubMed          Journal:  Mol Carcinog        ISSN： 0899-1987            Impact factor:   4.784


  118 in total

1.  Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment.

Authors:  Alba Gonzalez-Junca; Kyla E Driscoll; Ilenia Pellicciotta; Shisuo Du; Chen Hao Lo; Ritu Roy; Renate Parry; Iliana Tenvooren; Diana M Marquez; Matthew H Spitzer; Mary Helen Barcellos-Hoff
Journal:  Cancer Immunol Res       Date:  2018-12-11       Impact factor: 11.151

2.  Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.

Authors:  Kyung-Chul Choi; Youn Sook Lee; Seunghwan Lim; Hyo Kyoung Choi; Chang-Hun Lee; Eun-Kyung Lee; Suntaek Hong; In-Hoo Kim; Seong-Jin Kim; Seok Hee Park
Journal:  Nat Immunol       Date:  2006-09-03       Impact factor: 25.606

3.  TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet.

Authors:  Jack T Lin; Stacey L Martin; Luxi Xia; James D Gorham
Journal:  J Immunol       Date:  2005-05-15       Impact factor: 5.422

Review 4.  A role for TGFbeta signaling in the pathogenesis of psoriasis.

Authors:  Gangwen Han; Cortny A Williams; Kelli Salter; Pamela J Garl; Allen G Li; Xiao-Jing Wang
Journal:  J Invest Dermatol       Date:  2009-08-27       Impact factor: 8.551

5.  Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation.

Authors:  Sophia Bornstein; Ruth White; Stephen Malkoski; Masako Oka; Gangwen Han; Timothy Cleaver; Douglas Reh; Peter Andersen; Neil Gross; Susan Olson; Chuxia Deng; Shi-Long Lu; Xiao-Jing Wang
Journal:  J Clin Invest       Date:  2009-10-19       Impact factor: 14.808

6.  TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors.

Authors:  Shuang Fu; Nan Zhang; Adam C Yopp; Dongmei Chen; Minwei Mao; Dan Chen; Haojiang Zhang; Yaozhong Ding; Jonathan S Bromberg
Journal:  Am J Transplant       Date:  2004-10       Impact factor: 8.086

7.  Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.

Authors:  Robert L Ferris; George Blumenschein; Jerome Fayette; Joel Guigay; A Dimitrios Colevas; Lisa Licitra; Kevin Harrington; Stefan Kasper; Everett E Vokes; Caroline Even; Francis Worden; Nabil F Saba; Lara C Iglesias Docampo; Robert Haddad; Tamara Rordorf; Naomi Kiyota; Makoto Tahara; Manish Monga; Mark Lynch; William J Geese; Justin Kopit; James W Shaw; Maura L Gillison
Journal:  N Engl J Med       Date:  2016-10-08       Impact factor: 91.245

Review 8.  The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis.

Authors:  Emma J de Ruiter; Marc L Ooft; Lot A Devriese; Stefan M Willems
Journal:  Oncoimmunology       Date:  2017-08-09       Impact factor: 8.110

9.  TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Authors:  Sanjeev Mariathasan; Shannon J Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Yulei Wang; Edward E Kadel; Hartmut Koeppen; Jillian L Astarita; Rafael Cubas; Suchit Jhunjhunwala; Romain Banchereau; Yagai Yang; Yinghui Guan; Cecile Chalouni; James Ziai; Yasin Şenbabaoğlu; Stephen Santoro; Daniel Sheinson; Jeffrey Hung; Jennifer M Giltnane; Andrew A Pierce; Kathryn Mesh; Steve Lianoglou; Johannes Riegler; Richard A D Carano; Pontus Eriksson; Mattias Höglund; Loan Somarriba; Daniel L Halligan; Michiel S van der Heijden; Yohann Loriot; Jonathan E Rosenberg; Lawrence Fong; Ira Mellman; Daniel S Chen; Marjorie Green; Christina Derleth; Gregg D Fine; Priti S Hegde; Richard Bourgon; Thomas Powles
Journal:  Nature       Date:  2018-02-14       Impact factor: 49.962

10.  Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort.

Authors:  Laura Q M Chow; Robert Haddad; Shilpa Gupta; Amit Mahipal; Ranee Mehra; Makoto Tahara; Raanan Berger; Joseph Paul Eder; Barbara Burtness; Se-Hoon Lee; Bhumsuk Keam; Hyunseok Kang; Kei Muro; Jared Weiss; Ravit Geva; Chia-Chi Lin; Hyun Cheol Chung; Amy Meister; Marisa Dolled-Filhart; Kumudu Pathiraja; Jonathan D Cheng; Tanguy Y Seiwert
Journal:  J Clin Oncol       Date:  2016-09-30       Impact factor: 44.544
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  5 in total

1.  Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma.

Authors:  Alexander A Strait; Rachel A Woolaver; Spencer C Hall; Christian D Young; Sana D Karam; Antonio Jimeno; Yan Lan; David Raben; Jing H Wang; Xiao-Jing Wang
Journal:  Commun Biol       Date:  2021-08-25

Review 2.  The Role of Immune Modulatory Cytokines in the Tumor Microenvironments of Head and Neck Squamous Cell Carcinomas.

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Journal:  Cancers (Basel)       Date:  2022-06-11       Impact factor: 6.575

3.  Comparative Analysis of Mutation Status and Immune Landscape for Squamous Cell Carcinomas at Different Anatomical sites.

Authors:  Wenqi Ti; Tianhui Wei; Jianbo Wang; Yufeng Cheng
Journal:  Front Immunol       Date:  2022-07-22       Impact factor: 8.786

Review 4.  Leukoplakia and Immunology: New Chemoprevention Landscapes?

Authors:  Roberto Grigolato; Maria Eleonora Bizzoca; Luca Calabrese; Stefania Leuci; Michele Davide Mignogna; Lorenzo Lo Muzio
Journal:  Int J Mol Sci       Date:  2020-09-19       Impact factor: 5.923

Review 5.  Dual Role of p73 in Cancer Microenvironment and DNA Damage Response.

Authors:  Julian M Rozenberg; Svetlana Zvereva; Alexandra Dalina; Igor Blatov; Ilya Zubarev; Daniil Luppov; Alexander Bessmertnyi; Alexander Romanishin; Lamak Alsoulaiman; Vadim Kumeiko; Alexander Kagansky; Gerry Melino; Nikolai A Barlev
Journal:  Cells       Date:  2021-12-13       Impact factor: 6.600
  5 in total

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