Yunyun Zhang1, Shourong Lu1, Ying Yang1, Zhuo Wang1, Bin Wang1, Bingshan Zhang1, Jie Yu1, Wenwei Lu2, Mingluo Pan2, Jianxin Zhao2, Shenghua Guo3, Jin Cheng3, Xiaorong Chen3, Kan Hong4, Gang Li5, Zhiming Yu6. 1. Geriatric Department, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, 214000, China. 2. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, 214122, China. 3. Department of Medicine, Wuxi Xin'an Community Health Service Center, Wuxi, 214135, China. 4. Geriatric Department, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, 214000, China. 2898456291@qq.com. 5. Department of Neurology, Nanjing Medical University Affiliated Shanghai East Hospital, Shanghai, 200123, China. ligang@tongji.edu.cn. 6. Department of Cardiovascular, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, 214000, China. yuzhimi8660@sina.com.
Abstract
BACKGROUND: Diabetes is associated with a high risk of developing cognitive impairment, but the underlying mechanism remains unclear. Recent studies have found that gut microbiota may be involved in the progression of diabetes-associated cognitive impairment. AIMS: To analyze the diversity of gut microbiota in type 2 diabetes with or without cognitive impairment METHODS: 16S rRNA sequencing was used to detect the gut microbiota composition in 154 type 2 diabetes (T2DM) subjects RESULTS: Among 154 elderly T2DM participants included in our study, 73 with normal and 81 with impaired cognition. Lower levels of hemoglobin and HDL were observed in subjects with cognitive impairment. Patients with cognitive impairment had a lower abundance of Tenericutes. Comparison at the genus level revealed that T2DM patients with cognitive impairment had a decreased abundance of Bifidobacterium and unranked-RF39 and an increased abundance of Peptococcus and unranked-Leuconostocaceae. Additionally, the relative abundance of Veillonella and Pediococcus were decreased in subjects with cognitive impairment. Furthermore, the relative abundance of 7 sub-functions was significantly changed in the group with cognitive impairment. Calcium signaling pathways and the Renin-angiotensin system were upregulated in the cognitive impairment group while GnRH signaling, Fc gamma R-mediated phagocytosis, endocytosis, isoflavonoid biosynthesis, and cytochrome P450 were deregulated. CONCLUSION: Bifidobacterium may be associated with cognition in T2DM. Calcium signaling and renin-angiotensin system were shown to be associated with diabetes-associated cognitive impairment through gut microbiota.
BACKGROUND:Diabetes is associated with a high risk of developing cognitive impairment, but the underlying mechanism remains unclear. Recent studies have found that gut microbiota may be involved in the progression of diabetes-associated cognitive impairment. AIMS: To analyze the diversity of gut microbiota in type 2 diabetes with or without cognitive impairment METHODS: 16S rRNA sequencing was used to detect the gut microbiota composition in 154 type 2 diabetes (T2DM) subjects RESULTS: Among 154 elderly T2DM participants included in our study, 73 with normal and 81 with impaired cognition. Lower levels of hemoglobin and HDL were observed in subjects with cognitive impairment. Patients with cognitive impairment had a lower abundance of Tenericutes. Comparison at the genus level revealed that T2DM patients with cognitive impairment had a decreased abundance of Bifidobacterium and unranked-RF39 and an increased abundance of Peptococcus and unranked-Leuconostocaceae. Additionally, the relative abundance of Veillonella and Pediococcus were decreased in subjects with cognitive impairment. Furthermore, the relative abundance of 7 sub-functions was significantly changed in the group with cognitive impairment. Calcium signaling pathways and the Renin-angiotensin system were upregulated in the cognitive impairment group while GnRH signaling, Fc gamma R-mediated phagocytosis, endocytosis, isoflavonoid biosynthesis, and cytochrome P450 were deregulated. CONCLUSION: Bifidobacterium may be associated with cognition in T2DM. Calcium signaling and renin-angiotensin system were shown to be associated with diabetes-associated cognitive impairment through gut microbiota.
Entities:
Keywords:
Cognitive impairment; Gut microbiota; Type 2 diabetes (T2DM)
Authors: Irina S Sadovnikova; Artem P Gureev; Daria A Ignatyeva; Maria V Gryaznova; Ekaterina V Chernyshova; Ekaterina P Krutskikh; Anastasia G Novikova; Vasily N Popov Journal: Pharmaceuticals (Basel) Date: 2021-06-23