Literature DB >> 32300394

Toxic Hemolysis in a Young Healthy Female.

Ami Patel1, Swati Vishwanathan1, Abhishek Chilkulwar2, Prerna Mewawalla2.   

Abstract

Clostridium perfringes is a gram-positive, rod-shaped, anerobic, spore-forming pathogenic bacterium. C. perfringes is commonly known to cause tissue necrosis and gas gangrene. However, severe life-threatening complications like hemolysis due to clostridium sepsis are rarely encountered. We present a case of a 35-year-old female presenting with endometritis complicated with severe hemolysis in the setting of sepsis secondary to C. perfringes. Her hospital course was complicated with multi-organ involvement, requiring broad-spectrum intravenous antibiotics. Eventually, she made an uneventful recovery by early recognition of these rare complications and prompt institution of appropriate therapy. Copyright 2017, Patel et al.

Entities:  

Keywords:  Clostridium perfringes; Hemolysis; Toxic hemolysis

Year:  2017        PMID: 32300394      PMCID: PMC7155821          DOI: 10.14740/jh328w

Source DB:  PubMed          Journal:  J Hematol (Brossard)        ISSN: 1927-1212


  10 in total

Review 1.  Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature.

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Journal:  Neth J Med       Date:  2010-09       Impact factor: 1.422

2.  Epidemiological and pathobiological profiles of Clostridium perfringens infections: review of consecutive series of 33 cases over a 13-year period.

Authors:  Yuji Shindo; Yoh Dobashi; Toshiyasu Sakai; Chie Monma; Hiroyuki Miyatani; Yukio Yoshida
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

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Journal:  Am J Obstet Gynecol       Date:  1971-10-15       Impact factor: 8.661

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Authors:  W H Decker; W Hall
Journal:  Am J Obstet Gynecol       Date:  1966-06-01       Impact factor: 8.661

5.  Massive intravascular hemolysis in a patient infected by a Clostridium perfringens.

Authors:  Shoichiro Ohtani; Naomi Watanabe; Masashi Kawata; Kimiko Harada; Masahiro Himei; Kazuharu Murakami
Journal:  Acta Med Okayama       Date:  2006-12       Impact factor: 0.892

Review 6.  Clostridium perfringens alpha-toxin: characterization and mode of action.

Authors:  Jun Sakurai; Masahiro Nagahama; Masataka Oda
Journal:  J Biochem       Date:  2004-11       Impact factor: 3.387

Review 7.  Diagnosis and management of clostridium perfringens sepsis and uterine gas gangrene.

Authors:  Thomas F Halpin; Jane A Molinari
Journal:  Obstet Gynecol Surv       Date:  2002-01       Impact factor: 2.347

8.  Implication of plasma free hemoglobin in massive clostridial hemolysis.

Authors:  H R Terebelo; R L McCue; M S Lenneville
Journal:  JAMA       Date:  1982-10-22       Impact factor: 56.272

Review 9.  Clostridial sepsis with massive intravascular hemolysis: rapid diagnosis and successful treatment.

Authors:  B Bätge; W Filejski; V Kurowski; H Klüter; H Djonlagic
Journal:  Intensive Care Med       Date:  1992       Impact factor: 17.440

10.  Investigation of the pathogenesis of massive hemolysis in a case of Clostridium perfringens septicemia.

Authors:  W Hübl; B Mostbeck; H Hartleb; H Pointner; K Kofler; P M Bayer
Journal:  Ann Hematol       Date:  1993-09       Impact factor: 3.673

  10 in total

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