Literature DB >> 32299551

Effects of κ-carrageenan on pullulan's rheological and texture properties as well as pullulan hard capsule performances.

Yihui Zhang1, Ning Yang1, Yaqiong Zhang2, Jingwen Hou3, Huijie Han1, Zhu Jin1, Yuanyuan Shen1, Shengrong Guo4.   

Abstract

κ-Carrageenan (κ-Ca) is often used to facilitate gelling of aqueous solutions of polysaccharides. However, studies on its effects on pullulan's rheological and texture properties and pullulan (PUL) hard capsule performances have rarely been reported. Herein, effects of κ-Ca on PUL solutions, hydrogels, films and hard capsules were investigated. It was found that the gelling temperature of 15 % (w/w) PUL solutions with 0.07 % KCl increased from 34 ℃ to 42 ℃ as the concentration of κ-Ca increased from 0.6 % to 1.2 %, and the gelling temperature rose from 25 ℃ to 37 ℃ by adding a small amount of KCl (0.07 %) for 15 % PUL solutions with 0.9 % κ-Ca. As the κ-Ca concentration increased, hardness, fracturability and adhesiveness rose for PUL gels and tensile stress increased for PUL films. PUL capsules could be easily prepared by the aid of κ-Ca, and performances of capsules could be adjusted by changing the amount of κ-Ca.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Pullulan; Rheology; Texture property; κ-Carrageenan

Year:  2020        PMID: 32299551     DOI: 10.1016/j.carbpol.2020.116190

Source DB:  PubMed          Journal:  Carbohydr Polym        ISSN: 0144-8617            Impact factor:   9.381


  1 in total

1.  Comparison of HPMC Inhalation-Grade Capsules and Their Effect on Aerosol Performance Using Budesonide and Rifampicin DPI Formulations.

Authors:  Li Ding; Ashlee D Brunaugh; Rishi Thakkar; Christian Lee; Qingyan Jenny Zhao; Justin Kalafat; Mohammed Maniruzzaman; Hugh D C Smyth
Journal:  AAPS PharmSciTech       Date:  2022-01-11       Impact factor: 4.026

  1 in total

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