| Literature DB >> 32297745 |
Daniel G Anstis1, Ashley C Lindsay1, Tilo Söhnel1, Jonathan Sperry1.
Abstract
A short synthesis of the natural product polyaurine B is described. The 1,2,4-thiadiazole heterocycle was assembled using a Cu(II)-mediated heterocyclization reaction that forges the N-S bond. The final acylation step to install the methylcarbamate must be conducted under anhydrous, nonbasic conditions to prevent thiadiazole ring opening initiated by attack of hydroxide at C-5.Entities:
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Year: 2020 PMID： 32297745 DOI： 10.1021/acs.jnatprod.0c00166
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050